Table 1.
Baseline characteristics of women with hormone-receptor positive breast cancer by menopausal status and endocrine therapy use
| Premenopausal (n=1,472) | Postmenopausal (n=7,513) | |||||||
|---|---|---|---|---|---|---|---|---|
| Non-Users of Endocrine Therapy | Tamoxifen Users | p-value1 | Non-Users of Endocrine Therapy | Tamoxifen Users | p-value | Aromatase Inhibitor Users | p-value1 | |
| N (%) | 260 (17.7) | 1,212 (82.3) | 1,179 (15.7) | 546 (7.3) | 5,788 (77.0) | |||
| Follow-up time, years, Mean (SD) | 9.2 (2.8) | 8.8 (2.7) | 0.05 | 7.8 (4.0) | 8.1 (3.6) | 0.17 | 7.5 (4.0) | 0.03 |
| Age, years, Mean (SD) | 46.2 (4.7) | 44.0 (5.5) | <0.001 | 71.1 (11.2) | 66.6 (11.0) | <0.001 | 66.2 (8.9) | <0.001 |
| Race/ethnicity, n (%) | 0.001 | 0.69 | <0.001 | |||||
| White | 162 (62.3) | 586 (48.4) | 862 (73.1) | 392 (71.8) | 4054 (70.0) | |||
| Black | 20 (7.7) | 109 (9.0) | 74 (6.3) | 31 (5.7) | 338 (5.8) | |||
| Asian or Pacific Islander | 40 (15.4) | 299 (24.7) | 116 (9.8) | 61 (11.2) | 759 (13.1) | |||
| Hispanic | 37 (14.2) | 208 (17.2) | 110 (9.3) | 57 (10.4) | 603 (10.4) | |||
| American Indian or Alaskan Native | 1 (0.4) | 10 (0.8) | 17 (1.4) | 5 (0.9) | 34 (0.6) | |||
| Neighborhood median household income, Mean (SD) | $78,848 ($33,113) | $80,877 ($34,127) | 0.38 | $77,083 ($33,137) | $76,859 ($33,305) | 0.9 | $81,742 ($34,252) | <0.001 |
| Percent neighborhood education, Mean (SD) | ||||||||
| Less than high school | 12.2 (10.7) | 12.5 (11.6) | 0.67 | 12.0 (11.5) | 12.3 (11.2) | 0.59 | 11.7 (11.1) | 0.41 |
| High school or GED | 19.2 (10.7) | 19.8 (10.0) | 0.38 | 20.1 (10.3) | 20.6 (9.7) | 0.37 | 19.8 (10.1) | 0.41 |
| Some college | 31.4 (10.1) | 30.6 (10.3) | 0.24 | 30.6 (10.5) | 32.0 (10.4) | 0.01 | 30.5 (10.2) | 0.69 |
| College graduate or more | 37.2 (20.6) | 37.1 (20.3) | 0.94 | 37.2 (21.3) | 35.1 (20.0) | 0.04 | 37.9 (20.6) | 0.29 |
| AJCC Stage, n (%) | <0.001 | 0.001 | <0.001 | |||||
| Stage I | 184 (70.8) | 643 (53.1) | 907 (76.9) | 379 (69.4) | 3376 (58.3) | |||
| Stage II | 62 (23.9) | 473 (39.0) | 216 (18.3) | 142 (26.0) | 1900 (32.8) | |||
| Stage III | 14 (5.4) | 96 (7.9) | 56 (4.8) | 25 (4.6) | 512 (8.9) | |||
| Received chemotherapy, n (%) | 81 (31.5) | 690 (57.2) | <0.001 | 111 (9.5) | 101 (18.5) | <0.001 | 1722 (29.9) | <0.001 |
| Received radiation, n (%) | 135 (51.9) | 794 (65.5) | <0.001 | 582 (49.4) | 335 (61.4) | <0.001 | 3985 (68.9) | <0.001 |
| Had breast surgery, n (%) | 247 (95.0) | 1188 (98.0) | 0.005 | 1121 (95.1) | 541 (99.1) | <0.001 | 5675 (98.1) | <0.001 |
| Body mass index, kg/m2, Mean (SD) | 27.5 (6.9) | 27.5 (6.6) | 0.93 | 28.0 (6.3) | 27.4 (5.6) | 0.045 | 29.4 (6.4) | <0.001 |
| Body mass index category, n (%) | 0.95 | 0.42 | <0.001 | |||||
| Normal | 115 (44.2) | 538 (44.4) | 432 (36.6) | 218 (39.9) | 1572 (27.2) | |||
| Overweight | 74 (28.5) | 334 (27.6) | 387 (32.8) | 172 (31.5) | 1898 (32.8) | |||
| Obese | 71 (27.3) | 340 (28.1) | 360 (30.5) | 156 (28.6) | 2318 (40.1) | |||
| Smoking status 6 months prior to diagnosis, n (%) | 0.44 | 0.04 | 0.09 | |||||
| Never smoker | 160 (61.5) | 772 (63.7) | 605 (51.3) | 316 (57.9) | 3020 (52.2) | |||
| Current smoker | 33 (12.7) | 119 (9.8) | 93 (7.9) | 31 (5.7) | 465 (8.0) | |||
| Former smoker | 43 (16.5) | 224 (18.5) | 372 (31.6) | 161 (29.5) | 1892 (32.7) | |||
| Unknown | 24 (9.2) | 97 (8.0) | 109 (9.3) | 38 (7.0) | 411 (7.1) | |||
| Had diabetes at diagnosis, n (%) | 12 (4.6) | 57 (4.7) | 0.95 | 218 (18.5) | 71 (13.0) | 0.005 | 1018 (17.6) | 0.46 |
| Had dyslipidemia at diagnosis, n (%) | 40 (15.4) | 145 (12.0) | 0.13 | 615 (52.2) | 252 (46.2) | 0.02 | 3165 (54.7) | 0.11 |
| Had hypertension at diagnosis, n (%) | 30 (11.5) | 164 (13.5) | 0.39 | 672 (57.0) | 261 (47.8) | <0.001 | 3224 (55.7) | 0.41 |
| Had prevalent CVD at diagnosis, n (%) | 2 (0.8) | 3 (0.3) | 0.19 | 75 (6.4) | 18 (3.3) | 0.009 | 228 (3.9) | <0.001 |
1
Based on studentized T-test for continuous variables and Chi-square test for categorical variables. Abbreviations: AJCC, American Joint Committee on Cancer; CVD, cardiovascular disease; GED, general education degree; SD, standard deviation.