Table 1.
Characterization of target and non-targeted liposomes unloaded and loaded with Pan.
| Lipid composition (molar ratio) | (Pan/Lip)i (μg/μmol) | (PAN/Lip)f (μg/μmol) | E.E. (%) | Mean size (nm) (P.I.) | Zeta pot (mV) |
|---|---|---|---|---|---|
| PEG-Pan-Lip; DPPC:Chol:DSPE-PEG (1.85:1.0.15) | 39 ± 1 | 21 ± 1 | 56 ± 2 | 130 (< 0.050) | −2 ± 1 |
| FA-PEG-Pan-Lip; DPPC:Chol:DSPE-PEG: DSPE-PEG-FA (1.85:1.0.12:0.03) | 35 ± 1 | 33 ± 1 | 94 ± 2 | 130 (< 0.050) | −2 ± 1 |
| PEG- Lip; DPPC:Chol:DSPE-PEG (1.85:1.0.15) | na | na | na | 130 (< 0.070) | −3 ± 1 |
| FA-PEG-Lip; DPPC:Chol:DSPE-PEG: DSPE-PEG-FA (1.85:1.0.12:0.03) | na | na | na | 130 (< 0.070) | −3 ± 1 |
FA, Folate; (PAN/Lip)i, initial Pan to lipid ratio; (PAN/Lip)f, final Pan to lipid ratio; E.E., encapsulation efficiency; na, not applicable; P.I., polydispersity index.