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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: Methods Mol Biol. 2023;2709:277–286. doi: 10.1007/978-1-0716-3417-2_19

Table 2.

Plasma coagulation assessment: (Top) Results of Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), and Thrombin Time (TT) of Anti-Thrombin Fibers for Their Abilities in Delaying the Coagulation in Donors from the United States and Brazil, Displaying Some Minor Regional Variations; (Bottom) Restoration of Normal Coagulation Time by Addition of Kill-Switch Fibers [1]

Sample PT
APTT
TT
U.S. data (13.4 s) Brazil data (12.1 s) U.S. data (37.0 s) Brazil data (36.5 s) U.S. data (21.0 s) Brazil data (16.6 s)

NU fiber 17.3 ± 0.2 16.6 ± 0.3 >120.00 89.4 ± 1.4 >60.00 26.8 ± 0.2
RA fiber 16.6 ± 0.4 19.7 ± 0.2 70.9 ± 5.0 104.7 ± 1.9 >60.00 31.6 ± 0.6
NU/RA fiber 16.8 ± 0.4 17.7 ± 0.0 81.3 ± 4.3 100.4 ± 1.5 >60.00 28.6 ± 0.0
DNA-RNA fiber 11.8 ± 0.3 13.5 ± 0.2 36.7 ± 0.8 40.2 ± 0.1 15.8 ± 0.7 19.3 ± 0.1
Plasma 10.8 ± 0.2 13.6 ± 0.2 33.4 ± 1.2 28.6 ± 0.3 16.6 ± 0.3 19.4 ± 0.1
NU172 aptamer 10.9 ± 0.2 14.1 ± 0.2 38.0 ± 1.5 39.5 ± 0.1 15.3 ± 0.8 19.0 ± 0.2
RA-36 aptamer 11.3 ± 0.4 15.3 ± 0.5 41.5 ± 3.2 45.5 ± 0.8 16.6 ± 0.8 26.5 ± 0.5

Sample PT (13.4 s) APTT (37.0 s) TT (21.0 s)

Control (normal) 12.7 ± 0.2 36.8 ± 1.5 21.4 ± 0.6
Control (abnormal) 20.7 ± 0.4 71.8 ± 1.4 41.3 ± 1.4
Plasma 9.7 ± 0.0 29.4 ± 0.2 16.1 ± 0.3
NU172 aptamer 16.1 ± 0.5 37.9 ± 0.7 25.3 ± 1.8
RA-36 aptamer 17.3 ± 0.3 44.2 ± 0.6 45.0 ± 1.4
NU fiber 18.6 ± 1.7 101.7 ± 2.0 59.5 ± 0.5
NU fiber + kill-switch 10.9 ± 0.1 36.7 ± 0.2 17.5 ± 0.4
RA fiber 20.8 ± 0.1 89.9 ± 1.1 >60.00
RA fiber + kill-switch 13.7 ± 0.1 42.9 ± 0.3 44.7 ± 0.1
NU/RA fiber 16.8 ± 0.9 95.3 ± 3.0 >60.00
NU/RA fiber + kill-switch 10.6 ± 0.3 38.5 ± 0.4 18.4 ± 0.6