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. 2023 Aug 30;14:1217366. doi: 10.3389/fimmu.2023.1217366

Figure 2.

Figure 2

Panx1 mediates blood flow and dampens microcirculation. Panx1 regulates vascular tone in several ways. In VSMCs, adrenergic signals or phosphorylation by SFK opens Panx1 and leads to downstream Ca2+ signals, causing vasoconstriction. In vascular endothelial cells, Panx1 promotes activation of TRPV4 channel via purinergic signaling and enhances activity of NOS, leading to NO-dependent vasodilation. Activation of Panx1 hemichannels, which is widely distributed in the circulatory system, dampens microcirculation by promoting platelet aggregation and elevating venous permeability.