Fig. 1. The organotypic microfluidic device. Exploded view of the device with the tissue piece between two gaskets that define flow paths for luminal (above, red) and serosal (below, blue) media flows, respectively. A shows the components held within the middle piece of the device; two mesh pieces provide support above and below the tissue. Below shows a side view of the assembled device, with the flow paths for luminal (above, red) and serosal (below, blue) media flows.