Figure 4.

Odds ratio for association of genetically predicted systemic inflammatory regulators with Rapid3, CKDI25 and dialysis. IL, interleukin; TNF-a, tumor necrosis factor alpha; IFN-y, interferon gamma; MIP1bβ, macrophage inflammatory protein 1 beta; SCF, stem cell factor; MR, mendelian randomization; CI, confidence internal; OR, odds ratio; IVW-RE, inverse-variance weighted random- effects MR; SNP, single nucleotide polymorphism; Rapid3, rapid decline in renal function, i.e., a decline in eGFR of more than 3 mL/min/1.73 m² per year; CKDI25, rapid progression to chronic kidney disease (CKD), i.e., a decrease in eGFR ≥ 25% of baseline, along with progression from no CKD to CKD. P value for heterogeneity based on Cochran's Q statistic for IVW, and Rücker's Q for MR- Egger.