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. 2023 Sep 13;15(9):e45161. doi: 10.7759/cureus.45161

Table 3. Paired samples test of significance for each symptom.

  Test type Difference in proportions Asymptotic standard error Z Significance
  One-sided p Two-sided p
Pair 1: Difficulty breathing or shortness of breath - Difficulty breathing or shortness of breath post treatment McNemar .366 .075 3.873 .001 .001
Pair 2: Cough - Cough post treatment McNemar .195 .062 2.828 .002 .005
Pair 3: Fatigue or tiredness - Fatigue or tiredness post treatment McNemar .659 .074 5.196 .001 .001
Pair 4: Chest or stomach pain - Chest or stomach pain post treatment McNemar .195 .062 2.828 .002 .005
Pair 5: Joint or muscle pain - Joint or muscle pain post treatment McNemar .366 .075 3.873 .001 .001
Pair 6: Tachycardia or palpitations - Tachycardia or palpitations post treatment McNemar .171 .059 2.646 .004 .008
Pair 7: Symptoms that get worse after physical or mental activities - Symptoms that get worse after physical or mental activities post treatment McNemar .512 .078 4.583 .001 .001
Pair 8: Pins and needles feeling - Pins and needles feeling post treatment McNemar -.780 .065 -5.657 .001 .001
Pair 9: Diarrhea - Diarrhea post treatment McNemar .171 .059 2.646 .004 .008
Pair 10: Changes in taste or smell - Changes in taste or smell post treatment McNemar .244 .067 3.162 .001 .002
Pair 11: Fevers - Fevers post treatment McNemar -.976 .024 -6.325 .001 .001
Pair 12: Dizziness of lightheadedness when standing - Dizziness of lightheadedness when standing post treatment McNemar .317 .073 3.606 .001 .001
Pair 13: Difficulty sleeping - Difficulty sleeping post treatment McNemar .244 .067 3.162 .001 .002
Pair 14: Rash - Rash post treatment McNemar -.951 .034 -6.245 .001 .001
Pair 15: Mood changes - Mood changes post treatment McNemar .390 .076 4.000 .001 .001
Pair 16: Headache - Headache post treatment McNemar .317 .073 3.606 .001 .001
Pair 17: Brain fog or confusion - Brain fog or confusion post treatment McNemar .634 .075 5.099 .001 .001
Pair 18: Changes in menstruation - Changes in menstruation post treatment McNemar .098 .046 2.000 .023 .046