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. Author manuscript; available in PMC: 2023 Sep 13.
Published in final edited form as: Alzheimers Dement. 2022 Sep 24;19(4):1403–1414. doi: 10.1002/alz.12787

Figure 2. Associations between plasma and corresponding cerebrospinal fluid biomarkers.

Figure 2.

Scatter plots depict bivariate associations between plasma and CSF levels for Aβ42/40 ratio (A), p-tau217 (B), NfL (C) and GFAP (D) in BioFINDER-1 on the left-hand side and BioFINDER-2 on the right-hand side. To compare plasma coefficients between the base model and the one including creatinine and BMI as covariates, we generated 10 000 bootstrap samples of both models, shown in the histograms. Significant difference between models was based on the 95% confidence interval difference of the difference of plasma estimates between models.

Abbreviations: Aβ, beta-amyloid; BMI, body mass index; Crt: creatinine, CSF, cerebrospinal fluid, GFAP, glial fibrillary acidic protein; NfL, neurofilament light; p-tau217, phosphorylated tau 217