Table 3.

Plasma estimates related to conversion to dementia from logistic regressions in BioFINDER-1

	Aβ42/40 (Elecsys)		p-tau217		NfL		GFAP
	OR	AUC	OR	AUC	OR	AUC	OR	AUC
Conversion to AD-dementia within 4 years
Base model	0.54	0.70	3.87	0.82	1.66	0.67	1.98	0.74
Model including creatine and BMI	0.55	0.71	4.03	0.83	1.69	0.67	1.95	0.74
Conversion to all-cause dementia within 4 years
Base model	0.65	0.65	2.48	0.73	2.21	0.71	1.79	0.70
Model including creatine and BMI	0.65	0.67	2.46	0.74	2.31	0.71	1.78	0.71

Odds ratio of plasma biomarkers from logistic regression to discriminate participants who remained stable vs. those who converted to AD dementia or all-cause dementia. Odds ratio represents the increased odds of converting to dementia for each increase in standard deviation biomarker value. Models included age and sex as covariates. Bolded values indicate when significant improvement in plasma estimate was seen in models including creatinine and BMI based on bootstrapping. Significance of all plasma odds ratio is p < 0.001.

Abbreviations: Aβ, beta-amyloid; AUC, area under the curve; BMI, body mass index; GFAP, glial fibrillary acidic protein; NfL, neurofilament light; p-tau217, phosphorylated tau 217; OR, odds ratio