Fig. 10.

This figure shows the (A) histopathologic semiquantitative grading of local inflammatory reactions, consisting of polymorphonuclear cell infiltration, necrotizing inflammation, and mononuclear cell infiltration. Values are presented as means ± SDs (six per group). ^aGrade 0 = absent; 1 = minimal; 2 = slight; 3 = moderate; 4 = marked; 5 = massive or complete. (B) This image shows the histopathologic osteomyelitis evaluation severity scores of animals infected with Hi-SA5458 or Lo-SA5464 assessed at 4 and 14 days postoperatively. Acute features from left to right were osteonecrosis (gray), granulocyte infiltration (green), and soft tissue necrosis (blue). Chronic signs consisted of osteoneogenesis or fibrosis (orange) and mononuclear cell infiltration (white). The severity score is presented as means ± SDs (six per group).