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. 2023 Sep 13;9(37):eadh0831. doi: 10.1126/sciadv.adh0831

Fig. 4. Treatment of MUP-uPA/sgp130Fc mice with BGP-15 reduces inflammation and ER stress.

Fig. 4.

Liver samples were obtained at 40 weeks. RT-PCR analyses of Calr, a gene that encodes calreticulin; Pdia6, a gene that inhibits aggregation of misfolded proteins; hsp90aa1, a gene that encodes HSP90; dnajc3, a gene that encodes a protein that inhibits PKR; ppp1r3g, a gene that encodes protein phosphatase 1 regulatory subunit 3G; and ddit4l, a gene encoding DNA damage-inducible transcript 4–like protein, which inhibits cell growth by regulating the TOR signaling pathway (A). Representative image and quantification of XBP-1 mRNA splicing (B). Representative Western blot and quantification of CHOP (C), HSF1, p-eIF2α (D), p-JNK (E), and calreticulin (F). RT-PCR analyses of TNF (G), IL-4 (H), and EMR1, the gene that encodes the F4/80 protein (I). Unpaired t tests were used to analyze all data. The following numbers of biological replicates were used (independent mice) per group in each experiment: (A) 4; (B to F) 6 to 7; (G and I) 6; (H) 7 to 12. Data are expressed as means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.