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. 2023 Aug 30;14:1253568. doi: 10.3389/fimmu.2023.1253568
ADAM Adjuvant Avelumab in Merkel Cell Cancer
AEC 3-amino-9-ethylcarbazole
AMERK anti-Merkel cell panel
ANOVA analysis of variance
B16-LT B16F10 melanoma cells transduced with MCPyV-LTS220A
BCA bicinchoninic acid assay
CD cluster of differentiation
CpG cytosine-phosphorothioate-guanine
DAPI 4′,6-diamidino-2-phenylindole
DMSO dimethylsulfoxide
DNA deoxyribonucleic acid
ELISpot enzyme-linked immunosorbent spot
EM effector/memory
EP electroporation
FDA Food and Drug Administration
FIH first in human
GFP green fluorescent protein
GST glutathione S-transferase
HER2 human epidermal growth factor receptor 2
HPLC high-performance liquid chromatography
HRP horseradish peroxidase
IACUC Institutional Animal Care and Use Committee
ICI immune checkpoint inhibitor
ICS intracellular cytokine staining
ID intradermal
IL interleukin
IP intraperitoneal
ITI Immunomic Therapeutics Inc.
IFNγ interferon gamma
ITI-3000 DNA vaccine encoding a mutated form of MCPyV-LT and LAMP1
IV intravenous
LAMP1 lysosomal-associated membrane protein 1
LN lymph node
LT large T antigen
mRNA messenger ribonucleic acid
MCC Merkel cell carcinoma
MCPyV Merkel cell polyomavirus
MFI mean fluorescence intensity
MHC major histocompatibility complex
mIHC multispectral immunohistochemistry
mm millimeter
MOA mechanism of action
NEAD no evidence of active disease
NK natural killer
PBMC peripheral blood mononuclear cells
PD-1 programmed death ligand 1
pRB retinoblastoma protein
S220A mutation of serine to alanine at amino acid position 220
SOC standard of care
SOCS1 suppressor of cytokine signaling-1
ST small T antigen
STAMP Surgically Treated Adjuvant Merkel Cell Carcinoma with Pembrolizumab
TAM tumor-associated macrophage
Th T helper
TLR Toll-like receptor
tLT truncated large T antigen
TME tumor microenvironment
TNFα tumor necrosis factor alpha
Treg regulatory T cell
μg microgram
μM micrometer
UNITE ™ Universal Intracellular Targeted Expression
WT wild type