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. 2023 Aug 30;10:1187490. doi: 10.3389/fcvm.2023.1187490

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© 2023 Nguyen, Imanishi, Li, Chau, Banerjee, Velatooru, Ko, Samanthapudi, Lee, Abe, McBeath, Deswal, Lin, Palaskas, Dantzer, Fujiwara, Borchrdt, Turcios, Olmsted-Davis, Kotla, Cooke, Wang, Abe and Le.

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Increased EC inflammation and apoptosis in SENP2 S344A KI mice: (A) En face preparation of WT and SENP2 S344A KI aortas were immunofluorescence-stained with VCAM1 (red, EC inflammation) and VE-Cad (green, EC marker). (B) Aortic sections were stained with TUNEL (green, EC apoptosis (106)) and DAPI (blue, nucleus (9)). TUNEL-positive apoptotic nuclei were counted, indicating the colocalization between the TUNEL signal (representing fragmented DNA) and the DAPI signal (representing cell nuclei) (28). The graphs present quantified data from 5 independent samples (n = 5) (*p < 0.05, **p < 0.01, two-way ANOVA for (A); unpaired t-test for (B)).