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. 2023 Aug 30;10:1187490. doi: 10.3389/fcvm.2023.1187490

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© 2023 Nguyen, Imanishi, Li, Chau, Banerjee, Velatooru, Ko, Samanthapudi, Lee, Abe, McBeath, Deswal, Lin, Palaskas, Dantzer, Fujiwara, Borchrdt, Turcios, Olmsted-Davis, Kotla, Cooke, Wang, Abe and Le.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased EC activation-stimulated fibrosis in SENP2 S344A KI MLECs with upregulated expression of EC markers: (A) after L-flow, the Z-score of fibrosis-related processes is positively upregulated in SENP2 S344A KI MLECs, as determined by IPA analysis. (B) Under static condition, the Z-score of the pulmonary fibrosis idiopathic signaling pathway remains positive in SENP2 S344A KI MLECs. (C,D) Under static condition, the Z-score of EC activation-associated processes, including cell adhesion, angiogenesis, positive regulation of epithelial cell proliferation, and extracelular matrix organization, is positive in SENP2 S344A KI MLECs. (E) DNA synthesis is increased in HUVECs transduced with Ad-SENP2 S344A compared to HUVECs transduced with Ad-SENP2 WT, as demonstrated by data from 3 independent experiments. (F, left panel) The expression of mesenchymal markers (TWIST1, αSMA) is increased in SENP2 S344A KI MLECs. (F, right panel) The graphs present quantified data from 3 independent experiments (*p < 0.05, t-test). (G,H) The expression of both mesenchymal (G) and endothelial (H) markers is increased in SENP2 S344A KI MLECs.