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. 2023 Aug 30;14:1116392. doi: 10.3389/fimmu.2023.1116392

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Copyright © 2023 Ner-Gaon, Peleg, Gazit, Reiner-Benaim and Shay

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Splicing patterns in the human immune system. (A–D) Heatmap of the percent spliced in (PSI values) of the junctions with ΔPSI>=0.2 in differentially spliced LeafCutter clusters (DS-LC) that were identified in at least two human datasets. Each row represents a junction. Junctions in each dataset are sorted according to the clustering of the splicing patterns in that dataset. (A) GSE64655, (B) GSE60424, (C) GSE107011 and (D) GSE115736. (E) Bar plot of the counts of each alternative splicing (AS) type identified as differentially spliced in each dataset and in more than one dataset. DS-LCs that were not assigned alternative splicing type are labeled as an unknown type.