Table 2.
Histological factors associated with each electroanatomic characteristic
| Variables | Standardized coefficients | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | |||||||
| V biopsy | V GLA | %Fractionated EGM | SCZtotal | V biopsy | VGLA | %Fractionated EGM | SCZtotal | |
| %Fibrosis, % | –0.453*** | –0.451*** | 0.280*** | 0.377*** | –0.180* | –0.190* | 0.102 | 0.185* |
| %Intercellular space, % | –0.305*** | –0.322*** | 0.279*** | 0.356*** | –0.295*** | –0.274*** | 0.254** | 0.293*** |
| %Myofibrillar loss, % | –0.361*** | –0.291*** | 0.145* | 0.179** | –0.307*** | –0.236** | 0.160 | 0.175* |
| %Adipocyte, % | 0.089 | 0.056 | –0.166* | –0.040 | 0.107 | 0.056 | –0.152 | –0.004 |
| Myocyte size, µm | –0.011 | –0.097 | 0.104 | 0.191** | 0.143 | 0.100 | –0.033 | 0.075 |
| Nuclear density, /mm2 | 0.291*** | 0.372*** | –0.235*** | –0.303*** | 0.235** | 0.297*** | –0.153 | –0.131 |
| Myocyte disarray, 0,1,2,3 | –0.062 | –0.061 | –0.001 | 0.062 | 0.064 | 0.064 | –0.088 | –0.051 |
| Adjusted R2 | — | — | — | — | 0.334 | 0.322 | 0.154 | 0.233 |
*P < .05, **P < .01, ***P < .001; P value was adjusted using Benjamini–Hochberg method in multiple linear regression analysis; adjusted R2 (coefficient of determination) was calculated using all explanatory variables included in the multivariate model; SCZtotal, total width of slow conduction zones; Vbiopsy, voltage at the biopsy site; VGLA, global left atrial voltage; %Adipocyte, extent of adipocyte; %Fibrosis, extent of fibrosis; %Fractionated EGM, proportion of fractionated electrograms; %Intercellular space, extent of intercellular space; %Myofibrillar loss, severity of myofibrillar loss.