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. 2023 May 2;621(7978):396–403. doi: 10.1038/s41586-023-06127-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, In-solution stability of mRNAs upon incubation in buffer (Mg²⁺ = 20 mM) at 37 °C. Percentage of intact mRNA is shown. Data are presented as mean ± SD from three independent experiments. b, Protein expression of mRNAs following transfection into HEK293 cells for 24 h was determined by flow cytometry. Each group has three independent assays and 10,000 live cells were collected for analysis in each assay. MFI value is presented as mean ± s.d. Kruskal–Wallis analysis of variance (ANOVA) with Dunn’s multiple comparisons test to gE-Ther group was performed for statistical analysis. *P < 0.05, ***P < 0.001.