TABLE 1.
Sample characteristics of WRAP and Wisconsin ADRC participants.
| WRAP* N = 161 |
Wisconsin ADRC N = 154 |
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| Mean | SD | Mean | SD | |
| Age | 62.1 | 6.5 | 58.1 | 5.5 |
| Years of education | 16.2 | 2.2 | 16.2 | 2.3 |
| P-tau | 17.5 | 6.4 | 15.9 | 5.8 |
| T-tau | 200.6 | 67.3 | 184.5 | 69.3 |
| Aβ42 | 895.4 | 369.4 | 942.6 | 363.1 |
| Aβ40 | 14336.1 | 4497.9 | 13897.4 | 4742.3 |
| NfL | 87.2 | 38.0 | 83.3 | 80.7 |
| Neurogranin | 798.6 | 307.5 | 728.2 | 286.7 |
| YKL-40 | 144.6 | 48.3 | 128.7 | 39.1 |
| S100b | 1.1 | 0.3 | 1.2 | 0.3 |
| GFAP | 8.6 | 2.9 | 8.6 | 3.3 |
| sTREM2 | 7.9 | 2.4 | 7.6 | 2.1 |
| IL-6 | 4.3 | 2.6 | 5.2 | 3.7 |
| α-synuclein | 157.4 | 65.1 | 146.2 | 64.1 |
| N | % | N | % | |
| Sex | ||||
| Female | 105 | 65.2 | 106 | 68.8 |
| Male | 56 | 34.8 | 48 | 31.2 |
| Cognitive status | ||||
| Unimpaired stable | 129 | 80.1 | 154 | 100 |
| Unimpaired declining | 27 | 16.8 | ||
| Clinical MCI | 5 | 3.1 | ||
| No. of samples per individual | ||||
| 1 | 56 | 34.8 | 154 | 100 |
| 2 | 45 | 27.9 | ||
| 3 | 55 | 34.2 | ||
| 4 | 5 | 3.1 | ||
*The summary statistics of WRAP were based on each individual’s first available CSF collection where both metabolomics and biomarkers were measured.