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. 2023 Aug 4;72(8):1709–1717. doi: 10.1007/s00011-023-01774-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — PR3 activity in mouse BALF neutrophil lysate after treatment with BI 1291583 and subsequent LPS challenge, 11-day dosing. BALF bronchoalveolar lavage fluid, LPS lipopolysaccharide, p.o. orally, RFU relative fluorescence units, PR3 proteinase 3. ***p < 0.001 compared with vehicle. Samples were pooled for analysis of PR3 activity. Data are mean. Error bars depict standard error of the mean across duplicate experiments