Table 4.

Multivariable models identifying risk factors for > 10% drops in systolic blood pressure within 1 h after IV or PO nimodipine application

Patient group	Adjusted OR	95% CI	p value
IV group
Admission Hunt & Hess score	0.961	0.773–1.193	0.716
Female sex	1.283	0.665–2.473	0.457
Age, years	1.007	0.985–1.029	0.530
Mechanical ventilation	1.703	0.803–3.612	0.165
Days after ICU admission	0.855	0.629–1.162	0.317
Delayed cerebral ischemia	1.263	0.610–2.617	0.529
Median SBP at baseline, mm Hga	1.060	1.042–1.079	< 0.001*
PO group
Admission Hunt & Hess score	0.817	0.548–1.219	0.322
Female sex	1.665	0.819–3.384	0.159
Age, years	1.018	0.987–1.050	0.251
Mechanical ventilation	1.738	0.472–6.397	0.406
Days after ICU admission	0.981	0.827–1.165	0.829
Delayed cerebral ischemia	1.064	0.158–7.183	0.949
Median SBP at baseline, mm Hga	1.034	1.014–1.055	0.001*

Multivariable logistic regression analysis was done with generalized linear models (IV group) or generalized estimating equation models with an autoregressive correlation matrix (AR-1) to account for repeated measures (PO group)

CI confidence interval, ICU intensive care unit, IV intravenous, OR odds ratio, PO per os, SBP systolic blood pressure

^aThirty minutes before nimodipine application

*Statistically significant p <0.05