Table 3.

Pharmacokinetic parameters after oral administration of genistein and genistein-piperazine cocrystal in rats (x ± s, n = 6)

Parameter	Genistein	Genistein-piperazine
AUC(0-t) (ug/L*h)	2280.34 ± 296.29	3475.29 ± 598.98**
AUC(0-∞) (ug/L*h)	2355.71 ± 273.25	3791.34 ± 814.75**
MRT(0-t) (h)	7.63 ± 0.71	8.50 ± 0.26*
MRT(0-∞) (h)	8.41 ± 1.16	10.61 ± 0.91**
t1/2z (h)	4.02 ± 1.71	5.58 ± 1.94
Tmax (h)	5.67 ± 0.82	7.33 ± 1.03*
CLz/F (L/h/kg)	42.95 ± 5.16	36.28 ± 8.44
Vz/F (L/kg)	254.39 ± 117.43	274.61 ± 48.07
Cmax (ug/L)	307.49 ± 93.33	413.71 ± 105.32

**P < 0.01 between GEN and GEN-PPZ, *P < 0.05 between GEN and GEN-PPZ