Table II.

Tabular presentation for QUADAS-2 results.

Study	Risk of bias			Flow and timing	Applicability concerns
	Patient selection	Index test	Reference standard		Patient selection	Index test	Reference standard
Tashjian et al34 (USA)	□	□	□	□	▪	□	□
Akgün et al2 (Germany)	□	□	□	□	□	□	□
Dilisio et al6 (USA)	□	□	□	□	□	□	□
Doherty et al8 (UK)	□	□	□	□	?	□	□
Guild et al14 (USA)	□	□	□	□	?	□	□
Mederake et al21 (Germany)	□	□	□	□	□	□	□
Pruijn et al31 (Netherlands)	□	□	□	□	□	□	□

QUADAS-2, quality assessment of diagnostic accuracy studies-2.

□, low risk; ▪, high risk; ?, unclear risk.