Table 2.
Baseline and 6-month outcome measures stratified by clinical OA status.
| Outcome | Baseline |
6-Mo |
P-value | ||||
| OA (−) | OA (+) | Combined | OA (−) | OA (+) | Combined | ||
| Body Composition | |||||||
| BMI (kg/m2) | 35.3 ± 4.8 | 34.2 ± 4.6 | 34.6 ± 4.7 | 33.0 ± 4.4 | 31.7 ± 4.5 | 32.1 ± 4.4 | P < 0.0001† |
| Body Mass (% change) | – | – | - | −5.8 ± 4.1 | −6.3 ± 4.0 | −6.2 ± 4.0 | P < 0.0001† |
| Lean Body Mass (%) | 56.0 ± 6.0 | 56.3 ± 5.4 | 56.2 ± 5.6 | 58.8 ± 6.0 | 59.7 ± 6.0 | 59.4 ± 6.0 | P < 0.0001† |
| Fat Mass (%) | 44.0 ± 6.0 | 43.6 ± 5.7 | 43.8 ± 5.7 | 41.2 ± 6.0 | 40.4 ± 5.9 | 40.7 ± 5.9† | P < 0.0001† |
| Lean Body Mass (kg) | 54.2 ± 10.4 | 53.6 ± 10.0 | 53.8 ± 10.0 | 54.2 ± 10.6 | 52.9 ± 9.4 | 53.3 ± 9.8 | P = 0.224 |
| Fat Mass (kg) | 43.6 ± 9.2 | 41.2 ± 9.7 | 42.0 ± 8.9 | 37.8 ± 7.6 | 36.0 ± 8.8 | 36.6 ± 8.4 | P < 0.0001† |
| Biomarkers | |||||||
| Adiponectin Ln(ng/mL) | 9.5 ± 0.7 | 9.7 ± 0.8 | 9.6 ± 0.8 | 9.6 ± 0.7 | 9.7 ± 0.8 | 9.7 ± 0.7 | P = 0.0480† |
| COMP Ln(ng/mL) | 14.7 ± 0.5 | 14.5 ± 0.4 | 14.7 ± 0.4 | 14.4 ± 0.4 | 14.4 ± 0.4 | 14.4 ± 0.4 | P < 0.0001†,‡ |
| CRP Ln(ng/mL) | 10.6 ± 0.6 | 10.4 ± 0.5 | 10.5 ± 0.6 | 10.7 ± 0.7 | 10.3 ± 0.6 | 10.5 ± 0.5 | P = 0.710 |
| IL-6 Ln(pg/mL) | 2.0 ± 0.5 | 1.9 ± 0.7 | 1.9 ± 0.6 | 1.9 ± 0.5 | 1.8 ± 0.9 | 1.9 ± 0.8 | P = 0.414 |
| TNF- Ln(pg/mL) | 1.5 ± 0.7 | 1.2 ± 1.0 | 1.3 ± 0.9 | 1.4 ± 0.7 | 1.2 ± 0.8 | 1.3 ± 0.8 | P = 0.752 |
| Physical Function | |||||||
| SPPB (score) | 9.4 ± 1.2 | 9.1 ± 1.3 | 9.2 ± 1.3 | 11.3 ± 1.1 | 11.1 ± 1.5 | 11.1 ± 1.4 | P < 0.0001† |
| 6-Minute walk (m) | 474.4 ± 124.0 | 499.3 ± 86.7 | 485.4 ± 101.4 | 553.4 ± 77.3 | 524.3 ± 79.7 | 520.6 ± 99.9 | P = 0.091 |
| 8-Foot up and go (sec) | 7.6 ± 1.6 | 7.7 ± 2.0 | 7.6 ± 2.9 | 6.2 ± 0.9 | 7.1 ± 1.6 | 6.8 ± 1.4 | P < 0.0001† |
| 10-Chair Stands (sec) | 24.2 ± 7.7 | 25.5 ± 6.1 | 25.1 ± 6.6 | 19.3 ± 4.0 | 22.2 ± 6.4 | 21.2 ± 5.8 | P < 0.0001† |
| Left Hand Strength (kg) | 24.8 ± 8.3 | 23.7 ± 8.6 | 24.1 ± 8.4 | 25.3 ± 6.8 | 22.8 ± 9.0 | 23.7 ± 8.2 | P = 0.830 |
| Right Hand Strength (kg) | 25.9 ± 7.3 | 25.0 ± 8.9 | 25.4 ± 8.3 | 26.5 ± 7.3 | 24.5 ± 10.1 | 25.3 ± 9.1 | P = 0.910 |
Notes: Since analysis of dietary arm (i.e., standard protein vs higher protein) did not detect any effect of dietary arm on the outcome measures, subjects were stratified only by clinical OA status.
†p < 0.05 for group change from baseline to 6-Mo (See: ‘Pre-Post Changes’).
‡p < 0.05 for between OA group change from baseline to 6-Mo (See: ‘Impact of OA on Outcome Measures’).
OA (−) n = 20, OA (+) n = 39.
Data reported as mean ± SD or total number (%). Bolding highlights the differences in grouped values which were found to be different between the baseline and 6-Month timepoints.