Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 13;7:90. doi: 10.1038/s41698-023-00438-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a Flowchart representing study samples sent for OBP. b Table summarizing tissue timepoint for all AI and fulvestrant samples passing OBP. c Enriched gene sets for differentially expressed genes between different timepoints using paired samples from the same patients. Log2 fold-change are calculated using DESeq2 in the paired mode setting and used as ranked gene list for input to GSEA. The normalized enrichment score (NES) along with associated p values are used to generate this bubble plot. d GSEA enrichment plots for select gene sets under each of the three timepoint comparisons. e Heatmap depicting gene expression fluctuations for select genes under different functional groups during the course of therapy. f Multispectral immunofluorescence imaging of a paired pretreatment and on-treatment sample.