Table 3.
Treatment during First 7 days by AKI diagnostic criteria in SA-AKI patients
| Variable | AKI diagnostic criteria | p valueb | ||
|---|---|---|---|---|
| Urine output only, N = 5952a | Creatinine only, N = 4642a | Both, N = 2857a | ||
| Any | ||||
| Ventilation | 4147 (70%) | 2470 (53%) | 1908 (67%) | < 0.001 |
| Invasive ventilation | 3975 (67%) | 2302 (50%) | 1815 (64%) | < 0.001 |
| Non-invasive ventilation | 357 (6%) | 297 (6.4%) | 159 (5.6%) | 0.3 |
| Vasopressors | 3762 (63%) | 3476 (75%) | 2419 (85%) | < 0.001 |
| Diuretics | 2946 (49%) | 2106 (45%) | 1404 (49%) | < 0.001 |
| RRT | 164 (2.8%) | 827 (18%) | 1432 (50%) | < 0.001 |
| Nephrotoxic antibiotics | 1722 (29%) | 1694 (36%) | 1292 (45%) | < 0.001 |
| Days of intervention | ||||
| Ventilation | 2 (0, 5) | 1 (0, 4) | 2 (0, 6) | < 0.001 |
| Invasive ventilation | 2 (0, 5) | 0 (0, 3) | 2 (0, 6) | < 0.001 |
| Non-invasive ventilation | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.3 |
| Vasopressors | 2 (0, 5) | 1 (0, 4) | 2 (0, 6) | < 0.001 |
| RRT | 2 (0, 3) | 2 (0, 3) | 3 (1, 4) | < 0.001 |
| Diuretic | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | < 0.001 |
| Mean daily | ||||
| Fluid balance (mL) | 74.2 (− 487.9, 637.26) | − 171.56 (− 910.7, 508.88) | 369.76 (− 343.8, 1,124.77) | < 0.001 |
| NEE Score (ug/kg/min) | 0.03 (0.01, 0.08) | 0.05 (0.02, 0.12) | 0.08 (0.03, 0.21) | < 0.001 |
| Furosemide Dose (mg) | 40 (20, 60) | 40 (26.67, 75) | 53.33 (33.33, 93.12) | < 0.001 |
SA-AKI sepsis-associated acute kidney injury; RRT renal replacement therapy; NEE norepinephrine equivalent
aMedian (IQR) or frequency (%)
bPearson's Chi-squared test; Kruskal–Wallis rank sum test