Table 3.
Mean change from baseline in mean diurnal IOP (mmHg) of study eye at each post-treatment visit (ITT population, missing data imputed with Monte Carlo Markov Chain)
| Visit statistics | Netarsudil 0.02% QD N = 122 |
Ripasudil 0.4% BID N = 123 |
|
|---|---|---|---|
| Week 1 | Mean ± SE | − 4.34 ± 0.16 | − 2.81 ± 0.14 |
|
Difference from ripasudil 0.4% (Netarsudil − ripasudil)a |
− 1.53 | ||
| 95% CI | (− 1.94, − 1.11) | ||
| p valueb | < 0.0001 | ||
| Week 2 | Mean ± SE | − 4.60 ± 0.17 | − 2.85 ± 0.18 |
|
Difference from ripasudil 0.4% (Netarsudil − ripasudil)a |
− 1.75 | ||
| 95% CI | (− 2.23, − 1.27) | ||
| p valueb | < 0.0001 | ||
| Week 4 | Mean ± SE | − 4.65 ± 0.17 | − 2.98 ± 0.16 |
|
Difference from ripasudil 0.4% (Netarsudil − ripasudil)a |
− 1.67 | ||
| 95% CI | (− 2.13, − 1.21) | ||
| p valueb | < 0.0001 | ||
BID twice a day, CI confidence interval, IOP intraocular pressure, ITT intent-to-treat, N number of patients in the given treatment of ITT population, QD once a day, SD standard deviation
aDifference between the groups (netarsudil—ripasudil) was tested using t test
bCIs and p values are 2-sided