Table 1.
Multivariable associations of mosaic chromosomal alterations with HIV infection, smoking, and age
| Autosomal mCA | mLOY | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|||||||||
| Exposure | Subjects | N | % | Adjusted OR (95% CI) | P Value* | N | % | Adjusted OR (95% CI) | P-Value* |
|
|
|
|
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| HIV status | 0.09 | 0.13 | |||||||
| Without | 2840 | 102 | 3.6% | reference | 83 | 2.9% | reference | ||
| Living With | 3139 | 121 | 3.9% | 1.28 (0.96, 1.71) | 44 | 1.4% | 0.73 (0.49, 1.09) | ||
| Age, per decade | 5979 | 223 | 3.7% | 0.95 (0.49, 1.91) | 0.88 | 127 | 2.1% | 2.06 (0.64, 7.39) | 0.23 |
| Age2, per decade2 | 5979 | 223 | 3.7% | 1.05 (0.99, 1.12) | 0.13 | 127 | 2.1% | 1.04 (0.93, 1.15) | 0.46 |
| Smoking status | 0.54 | 0.29 | |||||||
| Never | 1817 | 63 | 3.5% | reference | 33 | 1.8% | reference | ||
| Former | 1988 | 83 | 4.2% | 1.01 (0.72, 1.42) | 65 | 3.3% | 1.30 (0.83, 2.05) | ||
| Current | 1863 | 64 | 3.4% | 1.20 (0.84, 1.73) | 25 | 1.3% | 1.54 (0.87, 2.69) | ||
*
Likelihood ratio test p-value
Abbreviations: CI confidence interval; mCA mosaic chromosomal alterations; OR odds ratio