TABLE 1.

Statistical summary of the effects of the semaglutide and varenicline combination on measurements in male and female rats. Vehicle (Veh), semaglutide (sem), varenicline (Var), semaglutide and varenicline in combination (Com).

Treatment effects after the combination of semaglutide and varenicline
Sex	Measurements	Statistical analysis	Vehvs.Sem	Vehvs.Var	Vehvs.Com	Varvs.Com	Semvs.Com
Males	Alcohol intake	F(3,69) = 39.90, p < 0.0001	p < 0.0001	p = 0.9941	p < 0.0001	p < 0.0001	p = 0.9331
	Preference for alcohol	F(3,69) = 12.87, p < 0.0001	p < 0.0001	p > 0.9999	p = 0.0025	p = 0.0020	p = 0.6356
	Water intake	F(3,69) = 1.01, p = 0.3947	—
	Total fluid intake	F(3,69) = 2.42, p = 0.0739	—
	Food intake	F(3,69) = 52.84, p < 0.0001	p < 0.0001	p = 0.3813	p < 0.0001	p < 0.0001	p = 0.8214
	Body weight change	F(3,69) = 193.50, p < 0.0001	p < 0.0001	p = 0.7284	p < 0.0001	p < 0.0001	p = 0.7871
Females	Alcohol intake	F(3,66) = 14.72, p < 0.0001	p = 0.0012	p = 0.6040	p = 0.0007	p < 0.0001	p = 0.9990
	Preference for alcohol	F(3,66) = 7.44, p = 0.0002	p = 0.0239	p = 0.8877	p = 0.0221	p = 0.0029	p > 0.9999
	Water intake	F(3,66) = 3.66, p = 0.0168	p = 0.7146	p = 0.9959	p = 0.0386	0.0214	p = 0.3430
	Total fluid intake	F(3,66) = 0.65, p = 0.5874	—
	Food intake	F(3,66) = 72.02, p < 0.0001	p < 0.0001	p = 0.9951	p < 0.0001	p < 0.0001	p > 0.9999
	Body weight change	F(3,66) = 44.33, p < 0.0001	p < 0.0001	p = 0.9990	p < 0.0001	p < 0.0001	p > 0.9999