TABLE 3.

Statistical summary of the effects of the semaglutide and high fat diet combination on alcohol intake in male and female rats. Vehicle (Veh), semaglutide (Sem), high fat diet (HFD), semaglutide and high fat diet in combination (Com).

Sex	Measurements	Statistical analysis		Vehvs.Sem	Vehvs.HFD	Vehvs.Com	HFDvs.Com	Semvs.Com
Males	Alcohol intake	Treatment	F(3,16) = 20.83, p < 0.0001	S1: p = 0.0007	S1: p = 0.0437	S1: p = 0.0010	S1: p = 5472	S1: p = 0.9993
		Time	F(2,32) = 2.13,p = 0.1354	S2: p < 0.0001	S2: p = 0.0022	S2: p < 0.0001	S2: p = 0.6484	S2: p = 0.9764
		Interaction	F(6,32) = 0.38, p = 0.8892	S3: p < 0.0001	S3: p = 0.0009	S3: p < 0.0001	S3: p = 0.5949	S2: p = 0.9695
	Alcohol preference	Treatment	F(3,16) = 5.24, p = 0.0104	S1: p = 0.1958	S1: p = 0.6120	S1: p = 0.0371	S1: p = 0.4130	S1: p = 0.8689
		Time	F(2,32) = 0.33, p = 0.7213	S2: p = 0.0069	S2: p = 0.2797	S2: p = 0.0023	S2: p = 0.2099	S2: p = 0.9814
		Interaction	F(6,32) = 0.69, p = 0.6574	S3: p = 0.1245	S3: p = 0.7215	S3: p = 0.0115	S3: p = 0.1420	S2: p = 0.7591
	Water intake	Treatment	F(3,16) = 2.08, p = 0.1440	S1: p = 0.6537	S1: p = 0.3007	S1: p = 0.3279	S1: p > 0.9999	S1: p = 0.9455
		Time	F(2,32) = 22.21, p < 0.0001	S2: p = 0.3872	S2: p = 0.1690	S2: p = 0.0003	S2: p = 0.1054	S2: p = 0.0337
		Interaction	F(6,32) = 3.59, p = 0.0078	S3: p = 0.6537	S3: p = 0.7494	S3: p = 0.3582	S3: p = 0.9136	S3: p = 0.9601
	Total fluid intake	Treatment	F(3,16) = 0.99, p = 0.4236	—
		Time	F(2,32) = 2.71, p = 0.0821
		Interaction	F(6,32) = 1.73, p = 0.1472
	Food intake	Treatment	F(3,16) = 26.99, p < 0.0001	S1: p < 0.0001	S1: p = 0.3675	S1: p < 0.0001	S1: p < 0.0001	S1: p = 0.3331
		Time	F(2,32) = 13.40, p < 0.0001	S2: p < 0.0001	S2: p = 0.1872	S2: p < 0.0001	S2: p < 0.0001	S2: p = 0.1725
		Interaction	F(6,32) = 3,77, p = 0.0059	S3: p = 0.0315	S3: p = 0.1219	S3: p = 0.0002	S3: p = 0.1015	S3: p = 0.3059
	Body weight change	Treatment	F(3,16) = 67.92, p < 0.0001	S1: p = 0.9967	S1: p = 0.9922	S1: p = 0.9433	S1: p = 0.9922	S1: p = 0.9851
		Time	F(2,32) = 100.10,p < 0.0001	S2: p = 0.9999	S2: p > 0.9999	S2: p = 0.9967	S2: p = 0.9967	S2: p = 0.9922
		Interaction	F(6,32) = 36.91, p < 0.0001	S3: p < 0.0001	S3: p = 0.6790	S3: p < 0.0001	S3: p < 0.0001	S3: p = 0.4630
Females	Alcohol intake	Treatment	F(3,16) = 5.44, p = 0.0090	S1: p = 0.0033	S1: p = 0.1520	S1: p = 0.0047	S1: p = 0.5056	S1: p = 0.9994
		Time	F(2,32) = 21.72, p < 0.0001	S2: p = 0.1917	S2: p = 0.5419	S2: p = 0.3819	S2: p = 0.9930	S2: p = 0.9752
		Interaction	F(6,32) = 1.23, p = 0.3194	S3: p = 0.0026	S3: p = 0.0480	S3: p = 0.0140	S3: p = 0.9627	S3: p = 0.4630
	Alcohol preference	Treatment	F(3,16) = 2.52, p = 0.0952
		Time	F(2,32) = 14.96, p < 0.0001
		Interaction	F(6,32) = 1.26, p = 0.3057
	Water intake	Treatment	F(3,16) = 0.73, p = 0.5502	—
		Time	F(2,32) = 0.33, p = 0.7231
		Interaction	F(6,32) = 0.87, p = 0.5296
	Total fluid intake	Treatment	F(3,16) = 0.40, p = 0.7553	—
		Time	F(2,32) = 2.22, p = 0.1255
		Interaction	F(6,32) = 1.09, p = 0.3902
	Food intake	Treatment	F(3,16) = 20.46, p < 0.0001	S1: p < 0.0001	S1: p = 0.3785	S1: p < 0.0001	S1: p < 0.0001	S1: p = 0.7074
		Time	F(2,32) = 18.78, p < 0.0001	S2: p = 0.0007	S2: p = 0.0203	S2: p < 0.0001	S2: p = 0.0020	S2: p = 0.0466
		Interaction	F(6,32) = 7.88, p < 0.0001	S3: p = 0.0298	S3: p = 0.0766	S3: p = 0.0009	S3: p = 0.3785	S3: p = 0.6164
	Body weight change	Treatment	F(3,16) = 48.85, p < 0.0001	S1: p = 0.1535	S1: p = 0.8906	S1: p = 0.9887	S1: p = 0.7310	S1: p = 0.0788
		Time	F(2,32) = 32.72, p < 0.0001	S2: p = 0.9998	S2: p = 0.9638	S2: p = 0.9952	S2: p = 0.9952	S2: p = 0.9887
		Interaction	F(6,32) = 19.10, p < 0.0001	S3: p < 0.0001	S3: p = 0.7761	S3: p < 0.0001	S3: p < 0.0001	S3: p = 0.0133