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. 2023 Aug 31;14:1180512. doi: 10.3389/fphar.2023.1180512

TABLE 3.

Statistical summary of the effects of the semaglutide and high fat diet combination on alcohol intake in male and female rats. Vehicle (Veh), semaglutide (Sem), high fat diet (HFD), semaglutide and high fat diet in combination (Com).

Sex Measurements Statistical analysis Vehvs.Sem Vehvs.HFD Vehvs.Com HFDvs.Com Semvs.Com
Males Alcohol intake Treatment F(3,16) = 20.83, p < 0.0001 S1: p = 0.0007 S1: p = 0.0437 S1: p = 0.0010 S1: p = 5472 S1: p = 0.9993
Time F(2,32) = 2.13,p = 0.1354 S2: p < 0.0001 S2: p = 0.0022 S2: p < 0.0001 S2: p = 0.6484 S2: p = 0.9764
Interaction F(6,32) = 0.38, p = 0.8892 S3: p < 0.0001 S3: p = 0.0009 S3: p < 0.0001 S3: p = 0.5949 S2: p = 0.9695
Alcohol preference Treatment F(3,16) = 5.24, p = 0.0104 S1: p = 0.1958 S1: p = 0.6120 S1: p = 0.0371 S1: p = 0.4130 S1: p = 0.8689
Time F(2,32) = 0.33, p = 0.7213 S2: p = 0.0069 S2: p = 0.2797 S2: p = 0.0023 S2: p = 0.2099 S2: p = 0.9814
Interaction F(6,32) = 0.69, p = 0.6574 S3: p = 0.1245 S3: p = 0.7215 S3: p = 0.0115 S3: p = 0.1420 S2: p = 0.7591
Water intake Treatment F(3,16) = 2.08, p = 0.1440 S1: p = 0.6537 S1: p = 0.3007 S1: p = 0.3279 S1: p > 0.9999 S1: p = 0.9455
Time F(2,32) = 22.21, p < 0.0001 S2: p = 0.3872 S2: p = 0.1690 S2: p = 0.0003 S2: p = 0.1054 S2: p = 0.0337
Interaction F(6,32) = 3.59, p = 0.0078 S3: p = 0.6537 S3: p = 0.7494 S3: p = 0.3582 S3: p = 0.9136 S3: p = 0.9601
Total fluid intake Treatment F(3,16) = 0.99, p = 0.4236 —
Time F(2,32) = 2.71, p = 0.0821
Interaction F(6,32) = 1.73, p = 0.1472
Food intake Treatment F(3,16) = 26.99, p < 0.0001 S1: p < 0.0001 S1: p = 0.3675 S1: p < 0.0001 S1: p < 0.0001 S1: p = 0.3331
Time F(2,32) = 13.40, p < 0.0001 S2: p < 0.0001 S2: p = 0.1872 S2: p < 0.0001 S2: p < 0.0001 S2: p = 0.1725
Interaction F(6,32) = 3,77, p = 0.0059 S3: p = 0.0315 S3: p = 0.1219 S3: p = 0.0002 S3: p = 0.1015 S3: p = 0.3059
Body weight change Treatment F(3,16) = 67.92, p < 0.0001 S1: p = 0.9967 S1: p = 0.9922 S1: p = 0.9433 S1: p = 0.9922 S1: p = 0.9851
Time F(2,32) = 100.10,p < 0.0001 S2: p = 0.9999 S2: p > 0.9999 S2: p = 0.9967 S2: p = 0.9967 S2: p = 0.9922
Interaction F(6,32) = 36.91, p < 0.0001 S3: p < 0.0001 S3: p = 0.6790 S3: p < 0.0001 S3: p < 0.0001 S3: p = 0.4630
Females Alcohol intake Treatment F(3,16) = 5.44, p = 0.0090 S1: p = 0.0033 S1: p = 0.1520 S1: p = 0.0047 S1: p = 0.5056 S1: p = 0.9994
Time F(2,32) = 21.72, p < 0.0001 S2: p = 0.1917 S2: p = 0.5419 S2: p = 0.3819 S2: p = 0.9930 S2: p = 0.9752
Interaction F(6,32) = 1.23, p = 0.3194 S3: p = 0.0026 S3: p = 0.0480 S3: p = 0.0140 S3: p = 0.9627 S3: p = 0.4630
Alcohol preference Treatment F(3,16) = 2.52, p = 0.0952
Time F(2,32) = 14.96, p < 0.0001
Interaction F(6,32) = 1.26, p = 0.3057
Water intake Treatment F(3,16) = 0.73, p = 0.5502 —
Time F(2,32) = 0.33, p = 0.7231
Interaction F(6,32) = 0.87, p = 0.5296
Total fluid intake Treatment F(3,16) = 0.40, p = 0.7553 —
Time F(2,32) = 2.22, p = 0.1255
Interaction F(6,32) = 1.09, p = 0.3902
Food intake Treatment F(3,16) = 20.46, p < 0.0001 S1: p < 0.0001 S1: p = 0.3785 S1: p < 0.0001 S1: p < 0.0001 S1: p = 0.7074
Time F(2,32) = 18.78, p < 0.0001 S2: p = 0.0007 S2: p = 0.0203 S2: p < 0.0001 S2: p = 0.0020 S2: p = 0.0466
Interaction F(6,32) = 7.88, p < 0.0001 S3: p = 0.0298 S3: p = 0.0766 S3: p = 0.0009 S3: p = 0.3785 S3: p = 0.6164
Body weight change Treatment F(3,16) = 48.85, p < 0.0001 S1: p = 0.1535 S1: p = 0.8906 S1: p = 0.9887 S1: p = 0.7310 S1: p = 0.0788
Time F(2,32) = 32.72, p < 0.0001 S2: p = 0.9998 S2: p = 0.9638 S2: p = 0.9952 S2: p = 0.9952 S2: p = 0.9887
Interaction F(6,32) = 19.10, p < 0.0001 S3: p < 0.0001 S3: p = 0.7761 S3: p < 0.0001 S3: p < 0.0001 S3: p = 0.0133