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. 2023 Sep 5;120(37):e2309870120. doi: 10.1073/pnas.2309870120

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Copyright © 2023 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Fig. 1. — SARS-CoV-2 Mpro inhibitory activity of quercetin and echinatin. (A) Inhibition of Mpro by quercetin by the FRET assay. (B) The fluorescence quenching effect of quercetin on MCA-AVLQ fragment. (C) The Mpro inhibition ratio and quenching ratio of quercetin were calculated (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns: not significant). (D) Inhibition of Mpro cleavage of ddRFP by quercetin based on the SDS-PAGE assay. Nirmatrelvir (Nir) was used as a positive control. (E) Inhibition of Mpro by echinatin by the FRET assay. (F) The fluorescence quenching effect of echinatin on MCA-AVLQ fragment. (G) The Mpro inhibition ratio and quenching ratio of echinatin were calculated (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns: not significant). (H) Inhibition of Mpro cleavage of ddRFP by echinatin based on the SDS-PAGE assay. Nirmatrelvir (Nir) was used as a positive control.