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. 2023 Sep 5;120(37):e2305494120. doi: 10.1073/pnas.2305494120

Fig. 4.

Fig. 4.

Cryo-EM structure of KRAS G12C bound to AMG510. (A) A refined atomic model (A, Left) and a cryo-EM density map (A, Right) covering the KRAS protein, with the AMG510 drug molecule bound. The GDP ligand is shown in orange, and the AMG510 drug is in green. (B) Comparison between the cryo-EM structure and a prior X-ray crystal structure of KRAS G12C bound to AMG510. (C) Conformational variation at the covalent bond between Cys12 and the AMG510 and an AMG510 analog in X-ray and cryo-EM structures. At the thioether attachment, the cryo-EM model resembles an X-ray crystal structure of a complex with an AMG510 analog.