Table 1.

Frequent gene cassette arrays in various integron types and their impact on antimicrobial tolerance in distinct species of bacteria (Sabbagh et al., 2021).

Bacteria	Integrons	Gene cassettes	Antibiotics associated with gene cassettes	References
Acinetobacter baumannii	I, II	blaCARB-2, aadA1, aadA2, aadB, dfrA1, dfrA7, dfrA1-gcuF, dfrA1- aadA1, dfr17-aadA5, dfr12-gcuF-aadA2, sat1.	Extended Spectrum Beta–Lactamase, Aminoglycosides, Trimethoprim	Liu et al. (2014), Domingues et al. (2015), and Akrami et al. (2017)
Klebsiella spp.	I, II, III	blaCARB-2 blaGES-1, aadA, aadA1, aadB, dfrA1, dfrA7, dfrA1-gcuF, dfrA1- aadA1a, dfr17-aadA5, dfr12-gcuFaadA2.	Extended Spectrum Beta- Lactamase, Trimethoprim, Aminoglycosides,	Wu et al. (2013) and Domingues et al. (2015)
Enterobacter spp	I	aadA1a, aadA2, dfrA7, dfrA1-aadA1a, dfr17-aadA5, dfr12-gcuF-aadA	Aminoglycosides, Trimethoprim	Marathe et al. (2015)
Enterococcus faecalis	I	aadA1a, dfr12-gcuF-aadA2, dfrA1- sat1-aadA1.	Aminoglycosides, Trimethoprim	Sabbagh et al. (2017)
Pseudomonas aeruginosa	I	aadA2, aadB, dfr17-aadA5, dfr12-gcuF- aadA2.	Aminoglycosides, Trimethoprim	Ghaly et al. (2020a)
Staphylococcus aureus	I	aadA1, aadA2, dfr17-aadA5, dfr12- gcuF-aadA2, aacA4-cmlA1	Aminoglycosides, Trimethoprim, Chloramphenicol	Sow et al. (2010)
Escherichia coli	I, II, III	aadA1, aadA2, aadA5 aadB, dfrA1, dfrA5, dfrA7 dfrA12, dfr14, dfrA17, dfrB2, dfrA1-gcuC, dfrA1-aadA1, dfr17-aadA5, dfr12-gcuF-aadA2, dfrA1-sat1-aadA1, dfrA1-sat2-aadA1, estX-sat2-aadA1, blaOXA-101-aac (6′)–Ib, ere2.	Aminoglycosides, Trimethoprim, Extended Spectrum BetaLactamase, Erythromycin.	Kadlec and Schwarz (2008) and Kargar et al. (2014)
Salmonella spp.	I, II	aadA, aadA1a, aadA2, aadA5, aadB, dfrA1, dfrA7, dfrA12, dfrA17, dfrA1- gcuF, dfrA1-aadA1a, dfr17-aadA5, dfr12-gcuF-aadA2, blaCARB-2.	Aminoglycosides, Trimethoprim, Extended Spectrum BetaLactamase.	Antunes et al. (2006) and Domingues et al. (2015)