Table 1.
Patient Characteristics Stratified by Serum Triglycerides Group
| Serum Triglycerides (mg/dL) | |||||||
|---|---|---|---|---|---|---|---|
| Total | <80 | 80-<120 | 120-<160 | 160-<200 | 200-<240 | ≥240 | |
| N(%) | 138,675 | 19,435(14%) | 29,922(22%) | 26,715(19%) | 19,631(14%) | 13,420(10%) | 29,552(21%) |
| eGFR(mL/min/1.73m2) | 73 [58,88] | 75 [60,90] | 73[58,88] | 72[57,87] | 72[57,87] | 72[57,88] | 74[58,91] |
| eGFR category (%) | |||||||
| G1/G2 | 72 | 75 | 72 | 71 | 70 | 71 | 72 |
| G3a | 18 | 16 | 18 | 19 | 19 | 19 | 17 |
| G3b | 8 | 7 | 8 | 9 | 9 | 9 | 9 |
| G4/G5 | 2 | 1 | 2 | 2 | 2 | 2 | 2 |
| Albuminuria Stage (%) | |||||||
| Al | 72 | 75 | 74 | 73 | 72 | 72 | 68 |
| A2 | 24 | 22 | 23 | 23 | 24 | 24 | 27 |
| A3 | 4 | 3 | 4 | 4 | 4 | 4 | 5 |
| Age (years) | 65±11 | 67±11 | 67±11 | 66±11 | 66±10 | 65±10 | 62±10 |
| Gender (% Female) | 3 | 2 | 2 | 3 | 3 | 3 | 3 |
| Race (%) | |||||||
| White | 81 | 70 | 78 | 82 | 84 | 85 | 86 |
| African American | 14 | 26 | 18 | 14 | 11 | 10 | 8 |
| Other | 5 | 4 | 5 | 4 | 5 | 5 | 5 |
| Hispanic Ethnicity (%) | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| CCI | 2[1,3] | 2[1,3] | 2[1,3] | 2[1,3] | 2[1,3] | 2[1,3] | 2[1,3] |
| Comorbid Conditions (%) | |||||||
| MI | 7 | 6 | 8 | 8 | 8 | 8 | 7 |
| CHF | 12 | 12 | 13 | 13 | 12 | 12 | 11 |
| PVD | 12 | 12 | 13 | 13 | 12 | 12 | 11 |
| Cerebrovascular Disease | 9 | 9 | 10 | 10 | 10 | 9 | 8 |
| Dementia | 2 | 2 | 2 | 1 | 2 | 2 | 1 |
| COPD | 17 | 16 | 17 | 17 | 17 | 17 | 17 |
| Liver Disease | 3 | 3 | 3 | 3 | 3 | 2 | 3 |
| Cancer | 11 | 12 | 12 | 12 | 11 | 11 | 9 |
| Anemia | 7 | 7 | 7 | 7 | 7 | 7 | 7 |
| Atrial Fibrillation | 7 | 7 | 7 | 7 | 7 | 6 | 6 |
| Hypertension | 85 | 82 | 85 | 85 | 85 | 85 | 85 |
| ISHD | 35 | 32 | 36 | 36 | 36 | 37 | 35 |
| Depression | 18 | 14 | 15 | 17 | 18 | 19 | 23 |
| Substance Abuse | 4 | 5 | 4 | 4 | 4 | 4 | 5 |
| Ever Smoking | 64 | 60 | 63 | 64 | 65 | 66 | 68 |
| Ever Alcoholism | 15 | 17 | 15 | 15 | 14 | 14 | 14 |
| Laboratory Measurements | |||||||
| Albumin (g/dL) | 4.0±0.4 | 3.9±0.4 | 4.0±0.4 | 4.0±0.4 | 4.1±0.4 | 4.1±0.4 | 4.1±0.4 |
| ALP (U/L) | 70[57,87] | 69[56,86] | 70[57,86] | 70[57,86] | 70[57,86] | 70[57,86] | 72[58,89] |
| AST (U/L) | 22[18,27] | 22[18,27] | 22[18,27] | 22 [18,27] | 22 [18,27] | 22[18,27] | 23[18,29] |
| ALT (U/L) | 25[18,35] | 22[17,32] | 23[17,33] | 24[18,34] | 25[18,35] | 25 [19,36] | 27[20,39] |
| Glucose (mg/dL) | 150.2±61.8 | 136.1±53.9 | 140.5±54.2 | 145.3±55.7 | 150.4±58.7 | 154.3±60.8 | 172.1±74.4 |
| Hemoglobin Ale (%) | 7.4±1.6 | 7.2±1.5 | 7.2±1.4 | 7.3±1.5 | 7.4±1.5 | 7.4±1.6 | 7.8±1.8 |
| Hemoglobin (g/dL) | 14.1±1.6 | 13.7±1.6 | 13.9±1.6 | 14.1±1.6 | 14.3±1.6 | 14.3±1.6 | 14.4±1.6 |
| WBC (x 103/mm3) | 7.3±2.7 | 6.8±2.5 | 7.2±2.7 | 7.3±2.7 | 7.5±2.9 | 7.5±2.3 | 7.6±2.6 |
| SBP (mmHg) | 136±19 | 135±19 | 136±19 | 136±19 | 136±19 | 136±19 | 137±19 |
| DBP (mmHg) | 74±11 | 72±11 | 73±11 | 73±11 | 74±11 | 74±11 | 75±11 |
| BMI (kg/m2) | 32±6 | 29±6 | 31±6 | 32±6 | 32±6 | 33±6 | 33±6 |
| Lipid Panel (mg/dL) | |||||||
| Triglycerides | 148[100,222] | 64[54,72] | 100[90,110] | 138[129,148] | 178[168,188] | 217[208,228] | 321 [271,416] |
| HDL | 38[33,46] | 46[39,56] | 41 [35,49] | 39[33,45] | 37[32,43] | 36[31,42] | 34[30,40] |
| Cholesterol | 164[142,190] | 147[128,169] | 153 [134,175] | 160[140,183] | 166[146,190] | 172[151,197] | 189[164,220] |
| LDL | 96[79,117] | 85[69,102] | 91 [76,110] | 96 [79,116] | 100[82,120] | 101 [85,124] | 105[86,129] |
| Medications (%) | |||||||
| Statin | 50 | 47 | 52 | 52 | 52 | 52 | 48 |
| Ezetimibe | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Non-statin | 12 | 7 | 8 | 11 | 12 | 14 | 19 |
| Fibrate | 8 | 3 | 5 | 7 | 8 | 10 | 14 |
| Niacin | 3 | 3 | 3 | 3 | 3 | 4 | 4 |
| Fish Oil | 0.3 | 0.2 | 0.2 | 0.3 | 0.3 | 0.5 | 0.6 |
| Bile Acid Sequestrants | 0.6 | 0.5 | 0.5 | 0.7 | 0.7 | 0.7 | 0.8 |
| RAAS inhibitor | 56 | 54 | 56 | 56 | 57 | 57 | 57 |
Data presented as mean ± standard deviation, median[interquartile range], or percentage, as appropriate.
Abbreviations: ALP; Alkaline Phosphatase, ALT; Alanine Aminotransferase, AST; Aspartate Aminotransferase, BMI; Body Mass Index, BUN; Blood Urea Nitrogen, CCI; Charlson Comorbidity Index, CHF; Congestive Heart Failure, CKD; Chronic Kidney Disease, COPD; Chronic Obstructive Pulmonary Disorder, DBP; Diastolic Blood Pressure, eGFR; estimated glomerular filtration rate, ESRD; end-stage renal disease, HDL; High Density Lipoprotein, ISHD; Ischemic Heart Disease, LDL; Low Density Lipoprotein, MI; Myocardial Infarction, PTSD; Post-traumatic Stress Disorder, PVD; Peripheral Vascular Disease, RAAS; renin-angiotensin aldosterone system, SBP; Systolic Blood Pressure, WBC; White Blood Cells Count