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. Author manuscript; available in PMC: 2023 Sep 14.
Published in final edited form as: J Med Chem. 2021 Aug 20;64(17):12790–12807. doi: 10.1021/acs.jmedchem.1c00837

Table 1.

Hit triage of compound 1

graphic file with name nihms-1929486-t0007.jpg
MIC 7H9/ADC/Tw (µM) 4.7
MIC 7H9/glucose/BSA/Tx (µM) 4.7
MIC 7H9/DPPC/cholesterol/BSA/Tx (µM) 4.7
MIC 7H9/cholesterol/BSA/Tx (µM) 4.7
IC90 in 7H9/2.5mM butyrate/pH6/0.1mM nitrite (µM) 6.25
HepG2 IC50 glucose (µM) >50
HepG2 IC50 galactose (µM) >50
Solubility (µM) 170

MIC - minimum inhibitory concentration against Mtb H37Rv; 7H9 - Middlebrook 7H9; ADC - Albumin-Dextrose-Catalase supplement; Tw – Tween 80; BSA – Bovine serum albumin; Tx – Tyloxapol; DPCC - Dipalmitoylphosphatidylcholine and cholesterol; IC50 - 50% inhibitory concentration; Solubility – Aqueous Solubility at pH 7.4