Table 2.

The associations of inflammatory markers with all-cause mortality and CVD mortality in postmenopausal women with osteoporosis or osteopenia

	All-cause mortality				CVD mortality
	Unadjusted Model		Adjusted Model		Unadjusted Model		Adjusted Model
Variables	HR (95%CI)	P	HR (95%CI)	P	HR (95%CI)	P	HR (95%CI)	P
NLR	1.24 (1.14–1.34)	< 0.001	1.17 (1.09–1.26)	< 0.001	1.21 (1.11–1.33)	< 0.001	1.16 (1.04–1.29)	0.007
PLR	1.06 (0.97–1.16)	0.224	1.05 (0.98–1.13)	0.131	1.00 (0.86–1.16)	0.972	0.98 (0.88–1.09)	0.669
MLR	1.36 (1.29–1.43)	< 0.001	1.16 (1.08–1.25)	< 0.001	1.41 (1.31–1.52)	< 0.001	1.18 (1.05–1.33)	0.005
SII	1.18 (1.10–1.26)	< 0.001	1.11 (1.04–1.18)	< 0.001	1.12 (1.00–1.26)	0.043	1.09 (0.97–1.23)	0.156
SIRI	1.36 (1.29–1.44)	< 0.001	1.21 (1.12–1.30)	< 0.001	1.37 (1.25–1.51)	< 0.001	1.27 (1.10–1.46)	< 0.001
AISI	1.26 (1.18–1.34)	< 0.001	1.13 (1.06–1.20)	< 0.001	1.24 (1.10–1.39)	< 0.001	1.15 (1.01–1.30)	0.032

AISI, neutrophil × monocyte × platelet /lymphocyte ratio, CI Confidence interval, CVD Cardiovascular disease, HR Hazard ratio, MLR Monocyte-to-lymphocyte ratio, NLR Neutrophil-to-lymphocyte ratio, PLR Platelet-to-lymphocyte ratio, SII Immune-inflammation index, SIRI Systemic inflammation response index

For the all-cause mortality, age, race, education, marital status, the severity of osteoporosis, poverty-to-income ratio (PIR), smoking status, total cholesterol, glucose, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), central obesity, history of CVD, history of fracture, diabetes, lipid-lowering drugs, osteoporosis drugs, occupation, and energy intake were adjusted for; adjusted covariates for the CVD mortality included age, race, education, marital status, the severity of osteoporosis, PIR, high density lipoprotein cholesterol (HDL-C), total cholesterol, glucose, SBP, DBP, BMI, central obesity, CVD history, fracture history, diabetes, lipid-lowering drugs, and occupation