Table 1.
Patient Demographics Prior to and Post-PSM
| Variables | Pre-PSM | Post-PSM | ||||||
|---|---|---|---|---|---|---|---|---|
| Dydrogesterone (N = 2,368) | Allylestrenol (N = 989) | P-value | SMD | Dydrogesterone (N = 989) | Allylestrenol (N = 989) | P-value | SMD | |
| Age (Years) | 33.00 [30.00, 36.00] | 33.00 [30.00, 36.00] | 0.035 | 0.110 | 33.00 [30.00, 36.00] | 33.00 [30.00, 36.00] | 0.396 | 0.052 |
| Type of infertility (%) | 0.189 | 0.051 | 0.368 | 0.043 | ||||
| Primary | 1217 (51.4) | 483 (48.8) | 462 (46.7) | 483 (48.8) | ||||
| Secondary | 1151 (48.6) | 506 (51.2) | 527 (53.3) | 506 (51.2) | ||||
| Years of infertility | 4.00 [2.00, 6.00] | 3.00 [2.00, 5.00] | < 0.001* | 0.119 | 3.00 [2.00, 5.00] | 3.00 [2.00, 5.00] | 0.771 | 0.029 |
| Basal hormone level | ||||||||
| FSH (mIU/mL) | 5.88 [4.86, 7.15] | 5.97 [4.89, 7.09] | 0.477 | 0.061 | 5.80 [4.73, 7.10] | 5.97 [4.89, 7.09] | 0.062 | 0.063 |
| LH (mIU/mL) | 4.00 [2.70, 5.75] | 3.78 [2.25, 5.52] | < 0.001* | 0.109 | 3.86 [2.44, 5.76] | 3.78 [2.25, 5.52] | 0.148 | 0.062 |
| E2 (pg/mL) | 36.29 [26.38, 48.52] | 34.84 [24.56, 45.86] | 0.015 | 0.051 | 34.64 [25.16, 45.99] | 34.84 [24.56, 45.86] | 0.515 | 0.022 |
| AFC | 13.00 [9.00, 20.00] | 14.00 [9.00, 21.00] | 0.003* | 0.109 | 14.00 [9.00, 22.00] | 14.00 [9.00, 21.00] | 0.607 | 0.029 |
| AMH (ng/ml) | 2.96 [1.74, 4.90] | 2.99 [1.72, 4.77] | 0.558 | 0.065 | 2.96 [1.71, 4.89] | 2.99 [1.72, 4.77] | 0.764 | 0.040 |
| Progesterone (ng/ml) | 0.45 [0.26, 0.68] | 0.22 [0.13, 0.35] | < 0.001* | 0.008 | 0.35 [0.20, 0.58] | 0.22 [0.13, 0.35] | < 0.001* | 0.018 |
| Hormone level on the day of hCG | ||||||||
| FSH (mIU/mL) | 12.41 [9.74, 16.09] | 12.39 [9.87, 15.24] | 0.264 | 0.112 | 12.07 [9.10, 15.42] | 12.39 [9.87, 15.24] | 0.099 | 0.009 |
| E2 (pg/ml) | 26.94 [16.50, 30.00] | 30.00 [16.74, 30.00] | 0.386 | 0.044 | 27.80 [16.45, 30.00] | 30.00 [16.74, 30.00] | 0.368 | 0.015 |
| LH (mIU/mL) | 1.61 [0.99, 2.65] | 1.46 [0.93, 2.74] | 0.065 | 0.017 | 1.38 [0.84, 2.55] | 1.46 [0.93, 2.74] | 0.151 | 0.022 |
| AFC | 12.00 [7.00, 17.00] | 12.00 [8.00, 17.00] | 0.068 | 0.060 | 12.00 [8.00, 18.00] | 12.00 [8.00, 17.00] | 0.850 | 0.030 |
| Progesterone (ng/ml) | 0.87 [0.58, 1.24] | 0.60 [0.36, 0.97] | 0.001* | 0.038 | 0.78 [0.47, 1.18] | 0.60 [0.36, 0.97] | < 0.001* | 0.049 |
| Ovarian Stimulation Protocol (%) | < 0.001* | 0.823 | 0.994 | 0.038 | ||||
| PPOS | 64 (2.7) | 32 (3.2) | 35 (3.5) | 32 (3.2) | ||||
| Mild stimulation protocol | 144 (6.1) | 21 (2.1) | 21 (2.1) | 21 (2.1) | ||||
| GnRH antagonist protocol | 404 (17.1) | 290 (29.3) | 302 (30.5) | 290 (29.3) | ||||
| Modified long protocol | 404 (17.1) | 394 (39.8) | 381 (38.5) | 394 (39.8) | ||||
| Long protocol | 1143 (48.3) | 171 (17.3) | 171 (17.3) | 171 (17.3) | ||||
| Luteal phase stimulation protocol | 118 (5.0) | 46 (4.7) | 43 (4.3) | 46 (4.7) | ||||
| Others | 91 (3.8) | 35 (3.5) | 36 (3.6) | 35 (3.5) | ||||
| Number of Miscarriages | 0.009* | 0.119 | 0.188 | 0.112 | ||||
| 0 | 2125 (89.7) | 902 (91.2) | 888 (89.8) | 902 (91.2) | ||||
| 1 | 216 (9.1) | 70 (7.1) | 88 (8.9) | 70 (7.1) | ||||
| 2 | 21 (0.9) | 11 (1.1) | 11 (1.1) | 11 (1.1) | ||||
| ≥ 3 | 6 (0.3) | 2 (0.2) | 2 (0.2) | 2 (0.2) | ||||
PSM propensity score matching, SMD standardized mean difference, FSH follicle stimulating hormone, LH luteinizing hormone; E2 estradiol, AFC antral follicle count, AMH anti- Müllerian hormone, hCG human chorionic gonadotropin, PPOS progestin-primed ovarian stimulation, GnRH gonadotropin-releasing hormone
*P < 0.05