Table 2.
Univariate analysis of variables associated with infection
| Variables | Training set | Infection group | Non-infection group | P value |
|---|---|---|---|---|
| (N = 4353) | (N = 2266) | (N = 2087) | ||
| Age | 56.00(49.00,67.00) | 56.00(49.00,66.00) | 56.00(50.00,67.00) | 0.544 |
| Sex | 3165(72.71) | 1710(75.46) | 1455(69.72) | < 0.001 |
| Hypertension | 497(11.42) | 241(10.64) | 256(12.27) | 0.100 |
| Diabetes | 722(16.59) | 412(18.18) | 310(14.85) | 0.004 |
| Smoking | 2057(47.25) | 1116(49.25) | 941(45.09) | 0.007 |
| Drinking | 1997(45.88) | 1107(48.85) | 890(42.64) | < 0.001 |
| Primary liver cancer | 474(10.89) | 217(9.58) | 257(12.31) | 0.004 |
| Family history of liver disease | 944(21.69) | 497(21.93) | 447(21.42) | 0.708 |
| HBV | 2798(64.28) | 1476(65.14) | 1322(63.34) | 0.230 |
| HCV | 184(4.23) | 83(3.66) | 101(4.84) | 0.064 |
| Alcoholic | 614(14.11) | 369(16.28) | 245(11.74) | < 0.001 |
| Autoimmunity | 339(7.79) | 149(6.58) | 190(9.10) | 0.002 |
| GIB | 798(18.33) | 520(22.95) | 278(13.32) | < 0.001 |
| Ascites | 164(3.77) | 84(3.71) | 80(3.83) | 0.890 |
| HE | 266(6.11) | 212(9.36) | 54(2.59) | < 0.001 |
| HF | 623(14.31) | 550(24.27) | 73(3.50) | < 0.001 |
| TP (IQR, g/L) | 64.70(58.60,71.70) | 62.20(56.50,68.30) | 67.60(61.20,74.20) | < 0.001 |
| TB (IQR, umol/L) | 29.60(17.30,71.80) | 46.20(21.60,164.40) | 22.50(14.70,37.60) | < 0.001 |
| Hemoglobin (IQR, g/L) | 108.00(84.00,127.00) | 103.00(81.00,123.00) | 113.00(89.00,131.00) | < 0.001 |
| Na (IQR, mmol/L) | 139.30(136.20,141.70) | 138.00(134.60,141.00) | 140.20(138.00,142.20) | < 0.001 |
| K (IQR, mmol/L) | 3.87(3.55,4.19) | 3.84(3.46,4.23) | 3.90(3.61,4.14) | 0.003 |
| ALB (IQR, g/L) | 31.20(27.30,35.40) | 29.00(26.00,32.78) | 33.70(29.90,38.00) | < 0.001 |
| PTA (IQR, %) | 63.60(49.00,78.00) | 54.80(40.00,68.93) | 72.00(60.00,85.00) | < 0.001 |
| BUN (IQR, mmol/L) | 5.40(4.11,7.36) | 5.80(4.22,8.42) | 5.13(4.03,6.66) | < 0.001 |
| Cr (IQR, umol/L) | 67.20(56.10,81.70) | 69.00(57.43,87.10) | 65.80(54.95,76.95) | < 0.001 |
| RBC count (IQR, ×109/L) | 3.51(2.88,4.11) | 3.32(2.73,3.96) | 3.69(3.08,4.26) | < 0.001 |
| WBC count (IQR, ×109/L) | 4.32(2.99,6.35) | 5.20(3.43,7.95) | 3.73(2.70,5.03) | < 0.001 |
| NLR (IQR) | 3.37(2.08,5.82) | 4.94(2.96,7.95) | 2.43(1.62,3.62) | < 0.001 |
HBV: hepatitis B virus; HCV: hepatitis C virus; GIB: gastrointestinal bleeding; HE: hepatic encephalopathy; HF: hepatic failure; TP: total protein; TB: total bilirubin; Na: blood sodium; K: blood potassium; ALB: albumin; PTA: prothrombin activity; BUN: blood urea nitrogen; Cr: creatinine; RBC: Red blood cell; WBC: white blood cell; NLR: neutrophils to lymphocytes ratio; IQR: interquartile range