Table 8.
GSVA of dataset TCGA-THCA
| ID | logFC | AveExpr | t | P.Value | adj.P.Val | B |
|---|---|---|---|---|---|---|
| HALLMARK_P53_PATHWAY | 0.3768218 | −0.004078401 | 10.83994615 | 4.55E-25 | 2.27E-23 | 46.01595841 |
| HALLMARK_COAGULATION | 0.351662583 | 0.026542729 | 10.169446 | 1.79E-22 | 4.47E-21 | 40.11138465 |
| HALLMARK_APICAL_JUNCTION | 0.344203346 | 0.006930155 | 9.824898314 | 3.48E-21 | 5.81E-20 | 37.17934661 |
| HALLMARK_NOTCH_SIGNALING | 0.346286083 | 6.75E-05 | 8.730404308 | 2.67E-17 | 3.34E-16 | 28.35876033 |
| HALLMARK_WNT_BETA_CATENIN_SIGNALING | 0.313712619 | 0.001714427 | 8.60273333 | 7.21E-17 | 7.21E-16 | 27.38117989 |
| HALLMARK_ESTROGEN_RESPONSE_LATE | 0.246999977 | −0.005090355 | 7.406798172 | 4.56E-13 | 3.80E-12 | 18.78240801 |
| HALLMARK_GLYCOLYSIS | 0.230715127 | −0.025801665 | 7.236615434 | 1.46E-12 | 1.04E-11 | 17.64418804 |
| HALLMARK_SPERMATOGENESIS | −0.18400436 | 0.022540546 | −6.962862507 | 9.02E-12 | 5.64E-11 | 15.85979406 |
| HALLMARK_MYOGENESIS | 0.208854604 | 0.006142073 | 6.797284334 | 2.64E-11 | 1.47E-10 | 14.80877068 |
| HALLMARK_APOPTOSIS | 0.248444169 | 0.002369153 | 6.604850516 | 8.97E-11 | 4.49E-10 | 13.61443837 |
| HALLMARK_BILE_ACID_METABOLISM | −0.193755909 | −0.017961356 | −6.432515059 | 2.62E-10 | 1.19E-09 | 12.56992725 |
| HALLMARK_ANGIOGENESIS | 0.270638324 | 0.018325637 | 6.158580293 | 1.37E-09 | 5.70E-09 | 10.9590967 |
| HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION | 0.27345893 | −0.006903902 | 6.089616622 | 2.05E-09 | 7.57E-09 | 10.56324111 |
| HALLMARK_UV_RESPONSE_DN | −0.229112411 | −0.014036771 | −6.084421437 | 2.12E-09 | 7.57E-09 | 10.53357921 |
| HALLMARK_HEDGEHOG_SIGNALING | 0.233524795 | 0.011435876 | 5.875581953 | 7.09E-09 | 2.36E-08 | 9.359738293 |
| HALLMARK_PEROXISOME | 0.190064602 | −0.015328465 | 5.840142485 | 8.67E-09 | 2.71E-08 | 9.164147388 |
| HALLMARK_COMPLEMENT | 0.213997193 | 0.01071676 | 5.572759969 | 3.84E-08 | 1.13E-07 | 7.722535311 |
| HALLMARK_PANCREAS_BETA_CELLS | −0.193223333 | 0.025798123 | −5.242827534 | 2.21E-07 | 6.15E-07 | 6.027629177 |
| HALLMARK_HEME_METABOLISM | −0.14661062 | −0.024793887 | −5.124415209 | 4.06E-07 | 1.07E-06 | 5.442245401 |
| HALLMARK_DNA_REPAIR | 0.19170106 | −0.031549682 | 5.022204723 | 6.80E-07 | 1.70E-06 | 4.94678652 |
| HALLMARK_IL2_STAT5_SIGNALING | 0.191173546 | 0.004378273 | 4.991166388 | 7.94E-07 | 1.89E-06 | 4.79814081 |
| HALLMARK_PI3K_AKT_MTOR_SIGNALING | 0.155921715 | −0.011818711 | 4.949434479 | 9.76E-07 | 2.22E-06 | 4.599616001 |
| HALLMARK_IL6_JAK_STAT3_SIGNALING | 0.22424914 | 0.011481255 | 4.657973659 | 3.96E-06 | 8.61E-06 | 3.255997571 |
| HALLMARK_MITOTIC_SPINDLE | 0.186334755 | −0.007088363 | 4.476217056 | 9.14E-06 | 1.90E-05 | 2.456427412 |
| HALLMARK_E2F_TARGETS | 0.190872349 | −0.018989981 | 4.34745323 | 1.63E-05 | 3.25E-05 | 1.907961071 |
| HALLMARK_ESTROGEN_RESPONSE_EARLY | 0.142950048 | −0.010095235 | 4.248926297 | 2.50E-05 | 4.81E-05 | 1.49842185 |
| HALLMARK_INTERFERON_ALPHA_RESPONSE | 0.238409428 | −0.01267727 | 4.178058187 | 3.39E-05 | 6.28E-05 | 1.209306136 |
| HALLMARK_CHOLESTEROL_HOMEOSTASIS | 0.1425821 | −0.019616323 | 4.163300613 | 3.61E-05 | 6.45E-05 | 1.149676545 |
| HALLMARK_KRAS_SIGNALING_UP | 0.148578458 | 0.019799344 | 3.942928279 | 9.03E-05 | 0.000155649 | 0.282953813 |
| HALLMARK_XENOBIOTIC_METABOLISM | 0.114377093 | 0.002609885 | 3.881845563 | 0.000115512 | 0.000192521 | 0.050616844 |
| HALLMARK_G2M_CHECKPOINT | 0.16673867 | −0.015764936 | 3.871545177 | 0.000120377 | 0.000194156 | 0.011777077 |
| HALLMARK_MYC_TARGETS_V2 | 0.178860851 | −0.031757686 | 3.845943568 | 0.000133318 | 0.00020831 | −0.084334535 |
| HALLMARK_INFLAMMATORY_RESPONSE | 0.175841487 | 0.009673152 | 3.713911853 | 0.000223687 | 0.000335263 | −0.5703618 |
| HALLMARK_MTORC1_SIGNALING | 0.139487603 | −0.024405819 | 3.708987262 | 0.000227979 | 0.000335263 | −0.588176985 |
| HALLMARK_MYC_TARGETS_V1 | 0.146721117 | −0.023428019 | 3.341085028 | 0.000887891 | 0.001268416 | −1.855055876 |
| HALLMARK_ALLOGRAFT_REJECTION | 0.164462076 | 0.003513032 | 3.135468432 | 0.001802173 | 0.002503018 | −2.507660456 |
| HALLMARK_INTERFERON_GAMMA_RESPONSE | 0.170036845 | −0.006403879 | 3.104776621 | 0.001996626 | 0.002698144 | −2.601639665 |
| HALLMARK_FATTY_ACID_METABOLISM | −0.107174508 | −0.032426209 | −2.788434403 | 0.005469218 | 0.00719634 | −3.51801593 |
| HALLMARK_UV_RESPONSE_UP | 0.085839529 | −0.016148619 | 2.745502217 | 0.006228212 | 0.007984887 | −3.635008025 |
| HALLMARK_UNFOLDED_PROTEIN_RESPONSE | −0.095138408 | −0.042398343 | −2.639344916 | 0.008528822 | 0.010661027 | −3.916691488 |
| HALLMARK_TNFA_SIGNALING_VIA_NFKB | 0.108173626 | −0.002192032 | 2.22853702 | 0.026225206 | 0.031981959 | −4.904261649 |
| HALLMARK_ANDROGEN_RESPONSE | −0.085541964 | 0.001682967 | −2.187375992 | 0.029111511 | 0.034656561 | −4.99419144 |
GSVA Gene set variation analysis