| 1.1 Change in participant‐reported ocular pain from baseline to 24 hours |
5 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 1.1.1 Anesthetic vs placebo, VAS (0 to 10), post‐surgery |
3 |
119 |
Mean Difference (IV, Random, 95% CI) |
‐1.28 [‐1.76, ‐0.80] |
| 1.1.2 Anesthetic vs placebo, VAS (0 to 10), post‐trauma |
1 |
76 |
Mean Difference (IV, Random, 95% CI) |
‐0.04 [‐0.10, 0.02] |
| 1.1.3 Anesthetic vs NSAID, VAS (0 to 10), post‐surgery |
1 |
74 |
Mean Difference (IV, Random, 95% CI) |
0.82 [0.01, 1.63] |
| 1.2 Change in participant‐reported ocular pain from baseline to 48 hours |
2 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.2.1 Anesthetic vs placebo, VAS (0 to 10), post‐surgery |
1 |
44 |
Mean Difference (IV, Fixed, 95% CI) |
0.41 [‐0.45, 1.27] |
| 1.2.2 Anesthetic vs placebo, VAS (0 to 10), post‐trauma |
1 |
111 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.68 [‐6.38, ‐4.98] |
| 1.3 Change in participant‐reported ocular pain from baseline to 72 hours |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
| 1.4 Proportion of post‐trauma participants without complete resolution of epithelial defects by 24 to 72 hours ‐ subgroup by tetracaine concentration |
3 |
221 |
Risk Ratio (M‐H, Random, 95% CI) |
1.37 [0.78, 2.42] |
| 1.4.1 Tetracaine 0.4% |
1 |
16 |
Risk Ratio (M‐H, Random, 95% CI) |
2.57 [0.29, 22.93] |
| 1.4.2 Tetracaine 0.5% |
1 |
112 |
Risk Ratio (M‐H, Random, 95% CI) |
1.67 [0.65, 4.27] |
| 1.4.3 Tetracaine 1% |
1 |
93 |
Risk Ratio (M‐H, Random, 95% CI) |
1.12 [0.53, 2.39] |
| 1.5 Proportion of participants without complete resolution of epithelial defects by 24 to 72 hours |
4 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 1.5.1 24 to 48 hours, post‐trauma |
3 |
221 |
Risk Ratio (M‐H, Random, 95% CI) |
1.37 [0.78, 2.42] |
| 1.5.2 48 hours or longer, post‐surgery |
1 |
30 |
Risk Ratio (M‐H, Random, 95% CI) |
0.14 [0.01, 2.55] |
| 1.6 Proportion of participants without complete resolution of epithelial defects by 24 to 72 hours ‐ subgroup by duration of use (RD) |
5 |
|
Risk Difference (M‐H, Random, 95% CI) |
Subtotals only |
| 1.6.1 24 to 48 hours, post‐trauma |
3 |
221 |
Risk Difference (M‐H, Random, 95% CI) |
0.06 [‐0.04, 0.16] |
| 1.6.2 24 to 48 hours, post‐surgery |
1 |
44 |
Risk Difference (M‐H, Random, 95% CI) |
0.00 [‐0.08, 0.08] |
| 1.6.3 48 hours or longer, post‐surgery |
1 |
30 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.20 [‐0.42, 0.02] |
| 1.7 Proportion of participants with complications at furthest time point |
4 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 1.7.1 At 1 week, post‐surgery |
1 |
44 |
Risk Ratio (M‐H, Random, 95% CI) |
7.00 [0.38, 128.02] |
| 1.7.2 At 1 to 2 weeks, post‐trauma |
3 |
242 |
Risk Ratio (M‐H, Random, 95% CI) |
1.13 [0.23, 5.46] |
| 1.8 Proportion of participants with complications at furthest time point (RD) ‐ subgroup by abrasion type |
7 |
394 |
Risk Difference (M‐H, Random, 95% CI) |
0.01 [‐0.03, 0.05] |
| 1.8.1 Post‐surgery |
3 |
119 |
Risk Difference (M‐H, Random, 95% CI) |
0.03 [‐0.06, 0.11] |
| 1.8.2 Post‐trauma |
4 |
275 |
Risk Difference (M‐H, Random, 95% CI) |
‐0.00 [‐0.06, 0.06] |
