FIGURE 6.

Presentation of platelet receptors and intracellular signaling among several kinds of cells. In platelet A, it shows that adhesion molecules on the platelets which can interact with endothelial cells, lymphocytes, other platelets. In platelet B, TXAS can generate TxA2, which can activate TP receptors. And cyclooxygenase‐1 (COX‐1) can synthesize PGH2, which can stimulate EP1 and EP3 receptors. In platelet C, the action of protease‐activated receptors (PAR1 and 4) can stimulate the platelets. Tumor cells can release ADP to activate P2Y1 or P2Y12 receptors. These targets provide possible therapies. Reproduced with permission from reference 37.