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a. Two NIS molecules entirely embedded in a detergent micelle, side view. An example of 2D classes representing the corresponding view is shown in the black square. b. NIS structure viewed from the plane of the membrane, with the numbered TM helices depicted as cylinders; c. Side view of NIS as in (c) but with solvent-accessible surface colored according to the electrostatic potential in kBT/e (red, negative; blue, positive).
