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. Author manuscript; available in PMC: 2023 Sep 14.
Published in final edited form as: Nature. 2022 Dec 14;612(7941):795–801. doi: 10.1038/s41586-022-05530-2

Extended Data Fig. 10 |. Apo-NIS structure with amino acids mutated in patients with ITDs shown as spheres.

Extended Data Fig. 10 |

Single amino acid substitutions are indicated by red spheres; deleted residues are in blue. The substitutions found in patients are: G18R, V59E, G93R, R124H, Q267E, V270E, D331N, Y348D, T354P, G395R, G543E, S547R, G561E and the deletion of 439–443 (ACNTP).