Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
a. Mechanism of NIS substrate binding, starting from the apo-NIS structure (grey rectangle). A hydrogen-bond network between F67, S69, Q72, and Y144 and a hydrophobic stacking interaction between F67 and Q72 are disrupted by the binding of the first Na+. This facilitates the binding of a second Na+ and subsequently of I−. b. Cartoon of the putative NIS transport cycle. The experimental structures are enclosed in grey and magenta boxes.
