Table 2.
Estimated hazard ratios for the type 2 diabetes incidence main study models
| Estimated hazard ratios | Model 1 | Model 2 |
|---|---|---|
| HR (95% CI) | HR (95% CI) | |
| PGS-SZ (per 1 SD) | 1.010 (0.932–1.095) | 1.037 (0.933–1.152) |
| Age (per 10 years) | 1.164 (1.047–1.294)** | 1.210 (1.067–1.373)** |
| Sex: women | 0.798 (0.668–0.954)* | 0.763 (0.586–0.993)* |
| BMI (per 5 kg/m2) | 1.572 (1.381–1.789)*** | |
| History of hypertension | 1.632 (1.348–1.976)*** | |
| History of cardiovascular diseases | 0.994 (0.721–1.372) | |
| Severe depressive symptoms | 1.352 (0.996–1.834) | |
| Triglycerides (mmol/l) | 1.112 (1.04–1.189)** | |
| HDL cholesterol (mmol/l) | 0.628 (0.385–1.025) | |
| History of stroke | 1.499 (0.972–2.312) | |
| Current smoking | 1.428 (1.095–1.864)** | |
| Exercise: light | 0.937 (0.606–1.451) | |
| Exercise: vigorous | 0.789 (0.602–1.036) | |
| Education: low | 1.448 (0.997–2.102) | |
| Education: medium | 1.342 (0.940–1.918) | |
| Wealth: medium | 1.021 (0.769–1.354) | |
| Wealth: low | 1.172 (0.894–1.537) | |
| PGS-T2DM (per 1 SD) | 1.335 (1.214–1.467)*** |
Model 1 adjusted for age, sex, genetic ancestry and schizophrenia polygenic score.
Model 2 adjusted for age, sex, genetic ancestry and schizophrenia polygenic score, BMI, hypertension, cardiovascular diseases, stroke, present severe depressive symptoms, blood triglycerides and HDL (mmol/l), current smoking (yes/no), exercise (light/moderate/vigorous; baseline level = moderate), wealth (low/medium/high; baseline level is “high”), education (low/medium/high, baseline level is “high”), polygenic score for T2DM.
CI, confidence interval, HR, hazard ratio, PGS-SZ, polygenic risk score for schizophrenia, T2DM, type 2 diabetes.
*P value <0.05 and above 0.01; **P value <0.01 and above 0.0001; ***P value <0.001.