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. 2023 Sep 14;222(10):e202309037. doi: 10.1083/jcb.202309037

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© 2023 Ikeda et al.

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Figure 1. — Roles of nucleoside diphosphate kinases in membrane dynamics. (A) NME1/2 fuel dynamin at the plasma membrane during endocytosis. (B) NME3 facilitates peroxisomal division, a process that is mediated by the dynamin-related GTPase Drp1, which also plays a role in mitochondrial division. (C) NME4 channels GTP to Opa1 for the fusion of the inner mitochondrial membrane (IMM). (D) NME3 promotes the fusion of the outer mitochondrial membrane (OMM) by tethering mitochondria. The localization of NME3 at mitochondrial contact sites depends on the phosphatidic acid produced by MitoPLD.