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. 2023 Mar 21;13(9):3930–3944. doi: 10.1016/j.apsb.2023.03.017

Figure 3.

Figure 3

The screening of natural products based on their inhibitory activity of IL-17A. (A) The experimental design of an ex vivo screening based on IL-17A-GFP reporter mice. (B) Illustrative flow cytometry plots of IL-17A-GFP gated on CD4+ T cells under Th17-priming conditions using splenic cells cultured for three days with 0.01% DMSO, 10 μmol/L aureane-type sesquiterpene tetraketides, or 1 μmol/L SR2211. SR2211 is set as a positive control. (C) Statistical histograms of IL-17A-GFP expression in CD4+ T cells. Data were reported as mean ± SD for n = 3. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 vs. DMSO group.