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. 2023 Mar 21;13(9):3930–3944. doi: 10.1016/j.apsb.2023.03.017

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© 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Compound 3 inhibits the expression of genes related to Th17 and glycolysis in the cells. (A) Heatmap shows the expression of Th17-associated genes on treatment with 5 μmol/L compound 3versus 0 μmol/L compound 3. The gene expression data were assessed by RNA-seq array. (B) qRT-PCR shows the fold change in representative Th17-related genes. (C) Top 20 signaling pathways enriched by the significant DEGs using KEGG pathway enrichment analysis. (D) ECAR was performed to compare the effect of different concentrations of compound 3 on glycolysis. (E and F) The bar graph shows glycolysis and glycolytic capacity in (D). The data were reported using the mean ± SD for n = 3. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 vs. compound 3 (0 μmol/L) group.