Figure 7.

Compound 3 attenuates hypoxia-induced PH. (A) Experimental schematic of the hypoxia-induced PH mouse model. (B) RVSP of mice subjected to normoxia with N4W + vehicle and hypoxia with H4W + vehicle or H4W + compound 3 for four weeks. (C) A selection of representative images demonstrating the H&E staining outcomes of pulmonary arterioles. These pulmonary arterioles are denoted by arrows. (D) The percentage of the pulmonary arteriole's medial thickness relative to its exterior diameter. (E) Weight gain in the three groups. (F and G) Illustrative of IHC staining images of IL-17A in the lung tissues and statistical histograms for mean density of IL-17A expression. Veh., Comp. 3, N4W, and H4W represent vehicle, compound 3, normoxia for four weeks, and hypoxia for four weeks, respectively. Data were represented as mean ± SEM. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 between indicated groups.