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Cell-based screening and structural modification of Taspine yields SMU-Y6. (A) SMU-Y6 exhibited less cytotoxicity, higher solubility and better activity in blocking TLR2 in preference to TLR4. It exerts its anti-inflammatory effect through the TLR2/MyD88/NF-κB and MAPK signaling pathway. (B) SMU-Y6 blocked TLR2/MyD88/NF-κB and MAPK signaling pathways to reduce the production of inflammatory cytokines and play an anti-inflammatory role.
